Bone marrow cells collected from normal donors and from patients with chronic myelogenous leukemia (CML) and cultures of the K562 leukaemic cell line, were investigated after treatment with hematin and low-energy gamma rays from a 57Co Mossbauer source. Different degrees of growth inhibition were observed for bone marrow cultures and for the leukaemic cell line K562. Exposure to light irradiation during sample treatments was also investigated. The results seem promising and it is author's belief that cell inactivation by Mossbauer effect could have future applications in the field of tumor pathology as an alternative to or in the support of conventional radiotherapy.
Inactivation of bone marrow cultures and K562 leukaemic cell line by Mossbauer effect / Ma, Wan Yun; Ortalli, Ida; Pedrazzi, Giuseppe; Vaccari, Silvia; Carlo Stella, Carmelo. - In: ANTICANCER RESEARCH. - ISSN 0250-7005. - 18:1 A(1998), pp. 419-423.
Inactivation of bone marrow cultures and K562 leukaemic cell line by Mossbauer effect
ORTALLI, Ida;PEDRAZZI, Giuseppe;VACCARI, Silvia;
1998-01-01
Abstract
Bone marrow cells collected from normal donors and from patients with chronic myelogenous leukemia (CML) and cultures of the K562 leukaemic cell line, were investigated after treatment with hematin and low-energy gamma rays from a 57Co Mossbauer source. Different degrees of growth inhibition were observed for bone marrow cultures and for the leukaemic cell line K562. Exposure to light irradiation during sample treatments was also investigated. The results seem promising and it is author's belief that cell inactivation by Mossbauer effect could have future applications in the field of tumor pathology as an alternative to or in the support of conventional radiotherapy.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
