The selective fluorescence zinc(II) sensing properties of a Schiff-base compound, 2-methoxy-6-(2-morpholinoethyliminomethyl)phenol (HL) have been explored. The emission intensity of HL in the presence of one equivalent of Zn2+ ion increases by about 25 times. Several other metal ions, except Cd2+ and Ni2+, have not been able to increase the emission intensity of HL significantly. The quantum yield and life-time of HL have also been increased in the presence of Zn2+ ions. The enhancement in fluorescence intensity of HL is mainly due to the restriction of ESIPT, CHEF and PET on complex formation. HL forms a complex with Zn2+ in 1:1 ratio as evidenced by Job's plot analysis and X-ray single crystal structure determination. Some theoretical calculations have been performed to get a better view on the nature of the observed electronic transitions. The probe has been applied for imaging of DLD-1, human colorectal adenocarcinoma cell.

A turn-on fluorescent chemosensor for Zn2+ ion: X-ray structure and application in cell imaging study / Ghosh, Koushik; Dey, Sudipto; Halder, Shibashis; Bhattacharjee, Aradhita; Rizzoli, Corrado; Roy, Partha. - In: JOURNAL OF MOLECULAR STRUCTURE. - ISSN 0022-2860. - 1118:(2016), pp. 325-334. [10.1016/j.molstruc.2016.04.006]

A turn-on fluorescent chemosensor for Zn2+ ion: X-ray structure and application in cell imaging study

RIZZOLI, Corrado;
2016-01-01

Abstract

The selective fluorescence zinc(II) sensing properties of a Schiff-base compound, 2-methoxy-6-(2-morpholinoethyliminomethyl)phenol (HL) have been explored. The emission intensity of HL in the presence of one equivalent of Zn2+ ion increases by about 25 times. Several other metal ions, except Cd2+ and Ni2+, have not been able to increase the emission intensity of HL significantly. The quantum yield and life-time of HL have also been increased in the presence of Zn2+ ions. The enhancement in fluorescence intensity of HL is mainly due to the restriction of ESIPT, CHEF and PET on complex formation. HL forms a complex with Zn2+ in 1:1 ratio as evidenced by Job's plot analysis and X-ray single crystal structure determination. Some theoretical calculations have been performed to get a better view on the nature of the observed electronic transitions. The probe has been applied for imaging of DLD-1, human colorectal adenocarcinoma cell.
2016
A turn-on fluorescent chemosensor for Zn2+ ion: X-ray structure and application in cell imaging study / Ghosh, Koushik; Dey, Sudipto; Halder, Shibashis; Bhattacharjee, Aradhita; Rizzoli, Corrado; Roy, Partha. - In: JOURNAL OF MOLECULAR STRUCTURE. - ISSN 0022-2860. - 1118:(2016), pp. 325-334. [10.1016/j.molstruc.2016.04.006]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2807974
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