We report herein a clean multistep flow process that starting from α,β-unsaturated ketones 1 allows the preparation of N-Boc-γ-amino alcohols 3 in high yields. The final products have been isolated in pure form without any additional purification step. The cleanness and environmental efficiency achieved using our protocol are proven by the calculation of green metrics such as E-factors.

An Efficient and Waste-Minimized One-Pot Procedure for the Preparation of N-Boc-γ-amino Alcohols Starting from α,β-Unsaturated Ketones in Flow / Ballerini, Eleonora; Maggi, Raimondo; Pizzo, Ferdinando; Piermatti, Oriana; Gelman, Dmitri; Vaccaro, Luigi. - In: ORGANIC PROCESS RESEARCH & DEVELOPMENT. - ISSN 1083-6160. - 20:2(2016), pp. 474-479. [10.1021/acs.oprd.5b00163]

An Efficient and Waste-Minimized One-Pot Procedure for the Preparation of N-Boc-γ-amino Alcohols Starting from α,β-Unsaturated Ketones in Flow

MAGGI, Raimondo;
2016

Abstract

We report herein a clean multistep flow process that starting from α,β-unsaturated ketones 1 allows the preparation of N-Boc-γ-amino alcohols 3 in high yields. The final products have been isolated in pure form without any additional purification step. The cleanness and environmental efficiency achieved using our protocol are proven by the calculation of green metrics such as E-factors.
An Efficient and Waste-Minimized One-Pot Procedure for the Preparation of N-Boc-γ-amino Alcohols Starting from α,β-Unsaturated Ketones in Flow / Ballerini, Eleonora; Maggi, Raimondo; Pizzo, Ferdinando; Piermatti, Oriana; Gelman, Dmitri; Vaccaro, Luigi. - In: ORGANIC PROCESS RESEARCH & DEVELOPMENT. - ISSN 1083-6160. - 20:2(2016), pp. 474-479. [10.1021/acs.oprd.5b00163]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11381/2807709
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