Rough titanium surfaces enhance the activation of Wnt canonical signaling, a pathway required for osteoblast differentiation. The present study investigated the effects of GSK3b-inhibitor (2’Z,3’E)- hydrophilic SLA titanium discs (modSLA) and stimulated with increasing doses of BIO. Activation of same cell system by Real Time PCR. Osteoblastic MC3T3 cells were then plated on discs with or without activated Wnt canonical signaling in C2C12 cells on all surfaces, and the highest effect was on rough rough surfaces at the concentration of 100 nM, and on all surfaces at the concentration of 1 mM. BIO be a viable approach to improve cell response to implant surfaces.
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