Methods and results The aauthors prospectively evaluated 28 MS patients (mean age 41±9 years, 12 males and 16 females) treated with low-dose mitoxantrone (basal mean cumulative dose 30±14 mg/m2, end of follow-up mean dose 41±17 mg/m2). All patients underwent two-dimensional and Doppler-echocardiography at baseline and after a mean follow-up of 22±8 months. MPI was estimated using mitral inflow and left ventricular (LV) outflow pattern. Comparing data at baseline and at the end of follow-up, significant decrease in ejection fraction (EF) was observed (60±5 vs 56±4, p<0.03). The MPI was 0.52±0.1 at baseline and 0.60±0.1 at the end of follow-up (p<0.04). Such difference was mainly due to a isovolumic relaxation time prolongation (80±12 at baseline and 98±30 at the end of follow-up, p<0.05). The area under the receiver operating characteristic curve, analysed for an MPI cut-point value of 0.57, in identifying a significant reduction of LVEF ≤50% was of 0.9460.065 with sensitivity and specificity of 97.5% and 90%, respectively. Conclusion In conclusion, it can be speculated that a higher basal value of MPI could represent a subclinical LV cardiotoxicity, identifying a future decrease of EF and a progression to congestive heart failure in MS patients under mitoxantrone therapy. Aims The authors sought to investigate the ability of the Doppler-derived myocardial performance index (MPI) to predict cardiotoxicity in multiple sclerosis (MS) patients under mitoxantrone therapy.

Usefulness of myocardial performance index in multiple sclerosis mitoxantrone-induced cardiotoxicity / Pattoneri, Paolo; Pela', Giovanna Maria; Montanari, Enrico; Pesci, Ilaria; Moruzzi, Paolo; Montanari, Alberto. - In: HEART ASIA. - ISSN 1759-1104. - 4:1(2014), pp. 91-94. [10.1136/heartasia-2012-010117]

Usefulness of myocardial performance index in multiple sclerosis mitoxantrone-induced cardiotoxicity

PATTONERI, Paolo;PELA', Giovanna Maria;MONTANARI, Enrico;PESCI, Ilaria;MONTANARI, Alberto
2014-01-01

Abstract

Methods and results The aauthors prospectively evaluated 28 MS patients (mean age 41±9 years, 12 males and 16 females) treated with low-dose mitoxantrone (basal mean cumulative dose 30±14 mg/m2, end of follow-up mean dose 41±17 mg/m2). All patients underwent two-dimensional and Doppler-echocardiography at baseline and after a mean follow-up of 22±8 months. MPI was estimated using mitral inflow and left ventricular (LV) outflow pattern. Comparing data at baseline and at the end of follow-up, significant decrease in ejection fraction (EF) was observed (60±5 vs 56±4, p<0.03). The MPI was 0.52±0.1 at baseline and 0.60±0.1 at the end of follow-up (p<0.04). Such difference was mainly due to a isovolumic relaxation time prolongation (80±12 at baseline and 98±30 at the end of follow-up, p<0.05). The area under the receiver operating characteristic curve, analysed for an MPI cut-point value of 0.57, in identifying a significant reduction of LVEF ≤50% was of 0.9460.065 with sensitivity and specificity of 97.5% and 90%, respectively. Conclusion In conclusion, it can be speculated that a higher basal value of MPI could represent a subclinical LV cardiotoxicity, identifying a future decrease of EF and a progression to congestive heart failure in MS patients under mitoxantrone therapy. Aims The authors sought to investigate the ability of the Doppler-derived myocardial performance index (MPI) to predict cardiotoxicity in multiple sclerosis (MS) patients under mitoxantrone therapy.
2014
Usefulness of myocardial performance index in multiple sclerosis mitoxantrone-induced cardiotoxicity / Pattoneri, Paolo; Pela', Giovanna Maria; Montanari, Enrico; Pesci, Ilaria; Moruzzi, Paolo; Montanari, Alberto. - In: HEART ASIA. - ISSN 1759-1104. - 4:1(2014), pp. 91-94. [10.1136/heartasia-2012-010117]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2799578
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