Two new complexes of antidiabetic drug metformin, [HMet]​[VO2(dipic)​]​·H2O (1) and [HMet]​[VO2(dipic-​OH)​]​·H2O (2)​, where H2dipic = 2,​6-​pyridinedicarboxylic acid, H2dipic-​OH = 4-​hydroxy-​2,​6-​pyridine dicarboxylic acid and Met = metformin, were synthesized. These complexes were characterized by elemental anal., 1H and 13C NMR, FTIR, and UV-​visible spectroscopies. Solid-​state structures of [HMet]​[VO2(dipic)​]​·H2O (monoclinic, P21/n) and [HMet]​[VO2(dipic-​OH)​]​·H2O (monoclinic, P21/c) were detd. by single crystal x-​ray diffraction anal. In these complexes, metformin is monoprotonated and acted as counterion. These compds. are sol. in water and hydrogen bond interactions stabilize their crystal structures.

Potential antidiabetic drugs of metformin with insulin-enhancing anions [VO2(dipic)]- and [VO2(dipic-OH)]-: Synthesis, characterization and X-ray crystal structure / Ghasemi, Khaled; Ghasemi, Fatemeh; Rezvani, Ali Reza; Graiff, Claudia; Notash, Behrouz. - In: POLYHEDRON. - ISSN 0277-5387. - 102(2015), pp. 239-245. [10.1016/j.poly.2015.09.053]

Potential antidiabetic drugs of metformin with insulin-enhancing anions [VO2(dipic)]- and [VO2(dipic-OH)]-: Synthesis, characterization and X-ray crystal structure

GRAIFF, Claudia;
2015

Abstract

Two new complexes of antidiabetic drug metformin, [HMet]​[VO2(dipic)​]​·H2O (1) and [HMet]​[VO2(dipic-​OH)​]​·H2O (2)​, where H2dipic = 2,​6-​pyridinedicarboxylic acid, H2dipic-​OH = 4-​hydroxy-​2,​6-​pyridine dicarboxylic acid and Met = metformin, were synthesized. These complexes were characterized by elemental anal., 1H and 13C NMR, FTIR, and UV-​visible spectroscopies. Solid-​state structures of [HMet]​[VO2(dipic)​]​·H2O (monoclinic, P21/n) and [HMet]​[VO2(dipic-​OH)​]​·H2O (monoclinic, P21/c) were detd. by single crystal x-​ray diffraction anal. In these complexes, metformin is monoprotonated and acted as counterion. These compds. are sol. in water and hydrogen bond interactions stabilize their crystal structures.
Potential antidiabetic drugs of metformin with insulin-enhancing anions [VO2(dipic)]- and [VO2(dipic-OH)]-: Synthesis, characterization and X-ray crystal structure / Ghasemi, Khaled; Ghasemi, Fatemeh; Rezvani, Ali Reza; Graiff, Claudia; Notash, Behrouz. - In: POLYHEDRON. - ISSN 0277-5387. - 102(2015), pp. 239-245. [10.1016/j.poly.2015.09.053]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11381/2798980
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