The pathophysiology of endotoxemia-induced acute kidney injury (AKI) is characterized by an intense activation of the host immune system and renal resident cells by lipopolysaccharide (LPS) and derived proinflammatory products. However, the occurrence of renal fibrosis in this setting has been poorly investigated. The aim of the present study was to investigate the possible association between endothelial dysfunction and acute development of tissue fibrosis in a swine model of LPS-induced AKI. Moreover, we studied the possible effects of coupled plasma filtration adsorption (CPFA) in this setting.
Endothelial dysfunction and renal fibrosis in endotoxemia-induced oliguric kidney injury: possible role of LPS-binding protein / Castellano, Giuseppe; Stasi, Alessandra; Intini, Angelica; Gigante, Margherita; Di Palma, Anna Maria; Divella, Chiara; Netti, Giuseppe Stefano; Prattichizzo, Clelia; Pontrelli, Paola; Crovace, Antonio; Staffieri, Francesco; Fiaccadori, Enrico; Brienza, Nicola; Grandaliano, Giuseppe; Pertosa, Giovanni; Gesualdo, Loreto. - In: CRITICAL CARE. - ISSN 1364-8535. - 18:5(2014), pp. 520-537. [10.1186/s13054-014-0520-2]
Endothelial dysfunction and renal fibrosis in endotoxemia-induced oliguric kidney injury: possible role of LPS-binding protein
FIACCADORI, Enrico;
2014-01-01
Abstract
The pathophysiology of endotoxemia-induced acute kidney injury (AKI) is characterized by an intense activation of the host immune system and renal resident cells by lipopolysaccharide (LPS) and derived proinflammatory products. However, the occurrence of renal fibrosis in this setting has been poorly investigated. The aim of the present study was to investigate the possible association between endothelial dysfunction and acute development of tissue fibrosis in a swine model of LPS-induced AKI. Moreover, we studied the possible effects of coupled plasma filtration adsorption (CPFA) in this setting.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
