ObjectiveThe aim of this research was to determine the prevalence and sonographic appearance of the hippocampal commissure in fetuses with isolated complete agenesis of the corpus callosum by three-dimensional neurosonography in the multiplanar mode. MethodsThis was a multicenter observational study. Stored volume datasets of fetuses with isolated complete agenesis of the corpus were retrospectively retrieved for analysis in three tertiary centers. The presence or absence of the hippocampal commissure was independently evaluated in the coronal and midsagittal planes by two operators. Postnatal follow-up was obtained in all cases. ResultsFrom November 2007 to February 2013, 41 cases between 19 and 30weeks of gestation were retrieved for analysis. The hippocampal commissure was visible in the coronal and sagittal planes in 27/41 (65.8%), absent or not clearly recognizable in the remaining 14 cases. The qualitative analysis of the two operators was concordant in 100% of cases. ConclusionsIn more than half of fetuses with complete callosal agenesis, the hippocampal commissure may be visualized at prenatal ultrasound. This is a residual interhemispheric connection, which in normal cases is hidden by the corpus callosum itself. Further research is needed to establish if this has an impact on postnatal outcome
The hippocampal commissure: A new finding at prenatal 3D ultrasound in fetuses with isolated complete agenesis of the corpus callosum / Contro, E; Nanni, M.; Bellussi, F.; Salsi, G.; Grisolia, G.; Sanz Cortès, M.; Righini, A.; Rizzo, N.; Pilu, G.; Ghi, Tullio. - In: PRENATAL DIAGNOSIS. - ISSN 0197-3851. - 35:9(2015), pp. 919-922. [10.1002/pd.4645]
The hippocampal commissure: A new finding at prenatal 3D ultrasound in fetuses with isolated complete agenesis of the corpus callosum
GHI, Tullio
2015-01-01
Abstract
ObjectiveThe aim of this research was to determine the prevalence and sonographic appearance of the hippocampal commissure in fetuses with isolated complete agenesis of the corpus callosum by three-dimensional neurosonography in the multiplanar mode. MethodsThis was a multicenter observational study. Stored volume datasets of fetuses with isolated complete agenesis of the corpus were retrospectively retrieved for analysis in three tertiary centers. The presence or absence of the hippocampal commissure was independently evaluated in the coronal and midsagittal planes by two operators. Postnatal follow-up was obtained in all cases. ResultsFrom November 2007 to February 2013, 41 cases between 19 and 30weeks of gestation were retrieved for analysis. The hippocampal commissure was visible in the coronal and sagittal planes in 27/41 (65.8%), absent or not clearly recognizable in the remaining 14 cases. The qualitative analysis of the two operators was concordant in 100% of cases. ConclusionsIn more than half of fetuses with complete callosal agenesis, the hippocampal commissure may be visualized at prenatal ultrasound. This is a residual interhemispheric connection, which in normal cases is hidden by the corpus callosum itself. Further research is needed to establish if this has an impact on postnatal outcomeI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.