The design and synthesis of a series of new fluorescent coumarin-containing melatonin analogues is presented. The combination of high-binding affinities for human melatonergic receptors (h-MT1R and h-MT2R) and fluorescent properties, derived from the inclusion of melatonin pharmacophoric elements in the coumarin scaffold, yielded suitable candidates for the development of MT1R and MT2R fluorescent probes for imaging in biological media.

New coumarin-based fluorescent melatonin ligands. Design, synthesis and pharmacological characterization / De La Fuente Revenga, Mario; Herrera Arozamena, Clara; Fernández Sáez, Nerea; Barco, Gema; García Orue, Itxaso; Sugden, David; Rivara, Silvia; Rodríguez Franco, María Isabel. - In: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. - ISSN 0223-5234. - 103:(2015), pp. 370-373. [10.1016/j.ejmech.2015.09.003]

New coumarin-based fluorescent melatonin ligands. Design, synthesis and pharmacological characterization

RIVARA, Silvia;
2015

Abstract

The design and synthesis of a series of new fluorescent coumarin-containing melatonin analogues is presented. The combination of high-binding affinities for human melatonergic receptors (h-MT1R and h-MT2R) and fluorescent properties, derived from the inclusion of melatonin pharmacophoric elements in the coumarin scaffold, yielded suitable candidates for the development of MT1R and MT2R fluorescent probes for imaging in biological media.
New coumarin-based fluorescent melatonin ligands. Design, synthesis and pharmacological characterization / De La Fuente Revenga, Mario; Herrera Arozamena, Clara; Fernández Sáez, Nerea; Barco, Gema; García Orue, Itxaso; Sugden, David; Rivara, Silvia; Rodríguez Franco, María Isabel. - In: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. - ISSN 0223-5234. - 103:(2015), pp. 370-373. [10.1016/j.ejmech.2015.09.003]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2797594
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