The Friedel-Crafts acylation of anisole with acetic anhydride could be efficiently catalyzed by suitable silica-supported sulfonic acids. In particular, by using silica supported 4-ethylphenylsulfonic acid as catalyst it was possible to apply the synthetic procedure to different aliphatic anhydrides and aromatic compounds. It has been observed that the effect of the length of the alkyl chain of the anhydride is quite significant. Moreover, some attempts to regenerate the solid catalyst have been also discussed
Friedel-Crafts acylation reaction catalyzed by silica supported sulfonic acids: synthetic aspects and limitations / Piscopo, Calogero Giancarlo; Maestri, Giovanni; Paris, Emanuele; Santacroce, Veronica; Maggi, Raimondo. - In: ARKIVOC. - ISSN 1551-7012. - 2015:7(2015), pp. 1-9. [10.3998/ark.5550190.p009.086]
Friedel-Crafts acylation reaction catalyzed by silica supported sulfonic acids: synthetic aspects and limitations
PISCOPO, Calogero Giancarlo;MAESTRI, Giovanni;PARIS, EMANUELE;SANTACROCE, Veronica;MAGGI, Raimondo
2015-01-01
Abstract
The Friedel-Crafts acylation of anisole with acetic anhydride could be efficiently catalyzed by suitable silica-supported sulfonic acids. In particular, by using silica supported 4-ethylphenylsulfonic acid as catalyst it was possible to apply the synthetic procedure to different aliphatic anhydrides and aromatic compounds. It has been observed that the effect of the length of the alkyl chain of the anhydride is quite significant. Moreover, some attempts to regenerate the solid catalyst have been also discussedI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
