Bifidobacteria are colonizers of the human gut, where they are interacting with their host as well as with other members of the intestinal microbiota. Teichoic acids (TAs) have previously been shown to play an important role in modulating microbe-host interactions in the human gut. However, so far, there is a paucity of information regarding the presence of TAs in the cell envelope of bifidobacteria. In silico analyses targeting the chromosomes of all 48 (sub)species that currently represent the genus Bifidobacterium revealed the presence of genes responsible for TA biosynthesis, suggesting that bifidobacteria contain both wall TAs and lipoteichoic acids. Transcriptome analyses of the infant gut commensal Bifidobacterium bifidum PRL2010 highlighted that the transcription of the presumptive TA biosynthetic loci is modulated in response to environmental conditions reflecting those of the human gut. Furthermore, chemical characterization of TAs produced by PRL2010 indicates the presence of lipoteichoic acids.

Insights into teichoic acid biosynthesis by Bifidobacterium bifidum PRL2010 / Colagiorgi, Angelo; Turroni, Francesca; Mancabelli, Leonardo; Serafini, Fausta; Secchi, Andrea; van Sinderen, D; Ventura, Marco. - In: FEMS MICROBIOLOGY LETTERS. - ISSN 0378-1097. - 362:17(2015). [10.1093/femsle/fnv141]

Insights into teichoic acid biosynthesis by Bifidobacterium bifidum PRL2010

COLAGIORGI, Angelo;TURRONI, FRANCESCA;MANCABELLI, Leonardo;SERAFINI, Fausta;SECCHI, Andrea;VENTURA, Marco
2015-01-01

Abstract

Bifidobacteria are colonizers of the human gut, where they are interacting with their host as well as with other members of the intestinal microbiota. Teichoic acids (TAs) have previously been shown to play an important role in modulating microbe-host interactions in the human gut. However, so far, there is a paucity of information regarding the presence of TAs in the cell envelope of bifidobacteria. In silico analyses targeting the chromosomes of all 48 (sub)species that currently represent the genus Bifidobacterium revealed the presence of genes responsible for TA biosynthesis, suggesting that bifidobacteria contain both wall TAs and lipoteichoic acids. Transcriptome analyses of the infant gut commensal Bifidobacterium bifidum PRL2010 highlighted that the transcription of the presumptive TA biosynthetic loci is modulated in response to environmental conditions reflecting those of the human gut. Furthermore, chemical characterization of TAs produced by PRL2010 indicates the presence of lipoteichoic acids.
Insights into teichoic acid biosynthesis by Bifidobacterium bifidum PRL2010 / Colagiorgi, Angelo; Turroni, Francesca; Mancabelli, Leonardo; Serafini, Fausta; Secchi, Andrea; van Sinderen, D; Ventura, Marco. - In: FEMS MICROBIOLOGY LETTERS. - ISSN 0378-1097. - 362:17(2015). [10.1093/femsle/fnv141]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2796696
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