This review focuses on antibodies (Abs) and their function in immune protection, with particular emphasis on microbicidal Abs. Some aspects of Abs and Ab-drug conjugates as targeting therapeutic agents are also discussed. The main aim, however, is devoted to Ab-derived peptides modulating functions of the immune system and to the latest experimental evidence of Abs as a source of anti-infective and antitumor peptides derived from their complementarity determining regions and constant regions.

Antibodies as a source of anti-infective peptides: an update / Magliani, Walter; Giovati, Laura; Ciociola, Tecla; Sperindè, Martina; Santinoli, Claudia; Conti, Giorgio; Conti, Stefania; Polonelli, Luciano. - In: FUTURE MICROBIOLOGY. - ISSN 1746-0913. - 10:7(2015), pp. 1163-1175. [10.2217/fmb.15.36]

Antibodies as a source of anti-infective peptides: an update

MAGLIANI, Valter;GIOVATI, Laura;CIOCIOLA, Tecla;SPERINDE', Martina;SANTINOLI, CLAUDIA;CONTI, Giorgio;CONTI, Stefania;POLONELLI, Luciano
2015

Abstract

This review focuses on antibodies (Abs) and their function in immune protection, with particular emphasis on microbicidal Abs. Some aspects of Abs and Ab-drug conjugates as targeting therapeutic agents are also discussed. The main aim, however, is devoted to Ab-derived peptides modulating functions of the immune system and to the latest experimental evidence of Abs as a source of anti-infective and antitumor peptides derived from their complementarity determining regions and constant regions.
Antibodies as a source of anti-infective peptides: an update / Magliani, Walter; Giovati, Laura; Ciociola, Tecla; Sperindè, Martina; Santinoli, Claudia; Conti, Giorgio; Conti, Stefania; Polonelli, Luciano. - In: FUTURE MICROBIOLOGY. - ISSN 1746-0913. - 10:7(2015), pp. 1163-1175. [10.2217/fmb.15.36]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2796596
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 8
  • ???jsp.display-item.citation.isi??? 8
social impact