In the present research, we prepare nanoparticles of Cu-TiO2 using different copper precursors with a solgel technique. In these nanobiocatalysts, titania was functionalized on the surfaces with sulfates, fosfates and GABA. We used intracranial glioma the C6 cell method for evaluating the efficiency and toxicity of the glioblastoma multiforme (GBM) tumor. The nanoparticles were tested in four groups of Wistar rats. To wit: 1-reference (normal); 2- C6 cells only; 3- tumor model used with different cooper complexes supported in TiO2. The following subdivision were: 3a- tumor model used with Cu(NH4)2 Cl4 /F-TiO2. 3b-Tumor model used with Cu(Oac)2/F-TiO2. 3c-Tumor model used with Cu(acac)2/F-TiO2. Finally, we add a 3d-titania reference. Immunohistochemical technique shows the following results: less inflammatory response as well as controlled gliosis. In addition a decrease in tumor size in each group.

Histology Study of Wistar Rats Implanted With and Without C6 Cells and the Effect of NPt-Cu Nanoparticles / López, Tessy; Islas, Emma Ortiz; Morales, Andrea; Cuevas, José Luis; Gomez, Esteban; Manjarrez, Joaquín; Guevara, Patricia; Tena, Martha Lilia; Sánchez, Aurora; Lottici, Pier Paolo; Bersani, Danilo; Monroy, Hugo; Novaro, Octavio. - In: JOURNAL OF NANOMEDICINE & BIOTHERAPEUTIC DISCOVERY. - ISSN 2155-983X. - 5:4(2015), pp. 1371-1377. [10.4172/2155-983X.1000137]

Histology Study of Wistar Rats Implanted With and Without C6 Cells and the Effect of NPt-Cu Nanoparticles

LOTTICI, Pier Paolo
Investigation
;
BERSANI, Danilo;
2015

Abstract

In the present research, we prepare nanoparticles of Cu-TiO2 using different copper precursors with a solgel technique. In these nanobiocatalysts, titania was functionalized on the surfaces with sulfates, fosfates and GABA. We used intracranial glioma the C6 cell method for evaluating the efficiency and toxicity of the glioblastoma multiforme (GBM) tumor. The nanoparticles were tested in four groups of Wistar rats. To wit: 1-reference (normal); 2- C6 cells only; 3- tumor model used with different cooper complexes supported in TiO2. The following subdivision were: 3a- tumor model used with Cu(NH4)2 Cl4 /F-TiO2. 3b-Tumor model used with Cu(Oac)2/F-TiO2. 3c-Tumor model used with Cu(acac)2/F-TiO2. Finally, we add a 3d-titania reference. Immunohistochemical technique shows the following results: less inflammatory response as well as controlled gliosis. In addition a decrease in tumor size in each group.
Histology Study of Wistar Rats Implanted With and Without C6 Cells and the Effect of NPt-Cu Nanoparticles / López, Tessy; Islas, Emma Ortiz; Morales, Andrea; Cuevas, José Luis; Gomez, Esteban; Manjarrez, Joaquín; Guevara, Patricia; Tena, Martha Lilia; Sánchez, Aurora; Lottici, Pier Paolo; Bersani, Danilo; Monroy, Hugo; Novaro, Octavio. - In: JOURNAL OF NANOMEDICINE & BIOTHERAPEUTIC DISCOVERY. - ISSN 2155-983X. - 5:4(2015), pp. 1371-1377. [10.4172/2155-983X.1000137]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2795534
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact