We describe herein a novel Pt(iv)-acetamidato complex as a result of the one-pot reaction between cisplatin and the highly reactive peroxyacetimidic acid generated in situ. This is the first example of a Pt(iv) complex containing a N-donor ligand coordinated during the Pt(ii) → Pt(iv) oxidation step. Remarkably, the Pt(iv)-amidato compound is highly soluble and stable in water; it represents an interesting building block for the further development of Pt(iv) antitumor prodrugs.
Unprecedented one-pot synthesis of an unsymmetrical cisplatin-based Pt(iv)-acetamidato complex / Pelosi, Giorgio; Ravera, Mauro; Gabano, Elisabetta; Fregonese, Federico; Osella, Domenico. - In: CHEMICAL COMMUNICATIONS. - ISSN 1364-548X. - 51:38(2015), pp. 8051-8053. [10.1039/c5cc02477c]
Unprecedented one-pot synthesis of an unsymmetrical cisplatin-based Pt(iv)-acetamidato complex
PELOSI, Giorgio;
2015-01-01
Abstract
We describe herein a novel Pt(iv)-acetamidato complex as a result of the one-pot reaction between cisplatin and the highly reactive peroxyacetimidic acid generated in situ. This is the first example of a Pt(iv) complex containing a N-donor ligand coordinated during the Pt(ii) → Pt(iv) oxidation step. Remarkably, the Pt(iv)-amidato compound is highly soluble and stable in water; it represents an interesting building block for the further development of Pt(iv) antitumor prodrugs.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
