In this work three capsule-based dry powder inhalers, available for generics product development, were compared. Two technologically different dry powder formulations were used in order to relate the capsule piercing position and motion in the device to their aerodynamic performance. A "pierce and inhale" design, in which the capsules pierced with RS01, HandiHaler or Turbospin devices were aerosolized in the same device or transferred and aerosolized with another device, was constructed and carried out. The results obtained showed that the two dry powder formulations, i.e., a drug/lactose blend or a carrier-free powder, aerosolized using the capsule based inhalers, performed differently. The aerosolization of drug carrier mixture in terms of drug dispersion and emitted dose, was more sensible to the piercing and device combination than the carrier free powder. The motion of the capsule during the aerosolization boosted the powder emission, whereas the powder disaggregation was more influenced by the airflow pattern around the capsule and inside the inhaler turbulence chamber.

"Pierce and inhale" design in capsule based dry powder inhalers: Effect of capsule piercing and motion on aerodynamic performance of drugs / Martinelli, Francesco; Balducci, Anna Giulia; Rossi, Alessandra; Sonvico, Fabio; Colombo, Paolo; Buttini, Francesca. - In: INTERNATIONAL JOURNAL OF PHARMACEUTICS. - ISSN 0378-5173. - 487:1-2(2015), pp. 197-204. [10.1016/j.ijpharm.2015.04.003]

"Pierce and inhale" design in capsule based dry powder inhalers: Effect of capsule piercing and motion on aerodynamic performance of drugs

MARTINELLI, Francesco;BALDUCCI, Anna Giulia;ROSSI, Alessandra;SONVICO, Fabio;COLOMBO, Paolo;BUTTINI, Francesca
2015-01-01

Abstract

In this work three capsule-based dry powder inhalers, available for generics product development, were compared. Two technologically different dry powder formulations were used in order to relate the capsule piercing position and motion in the device to their aerodynamic performance. A "pierce and inhale" design, in which the capsules pierced with RS01, HandiHaler or Turbospin devices were aerosolized in the same device or transferred and aerosolized with another device, was constructed and carried out. The results obtained showed that the two dry powder formulations, i.e., a drug/lactose blend or a carrier-free powder, aerosolized using the capsule based inhalers, performed differently. The aerosolization of drug carrier mixture in terms of drug dispersion and emitted dose, was more sensible to the piercing and device combination than the carrier free powder. The motion of the capsule during the aerosolization boosted the powder emission, whereas the powder disaggregation was more influenced by the airflow pattern around the capsule and inside the inhaler turbulence chamber.
2015
"Pierce and inhale" design in capsule based dry powder inhalers: Effect of capsule piercing and motion on aerodynamic performance of drugs / Martinelli, Francesco; Balducci, Anna Giulia; Rossi, Alessandra; Sonvico, Fabio; Colombo, Paolo; Buttini, Francesca. - In: INTERNATIONAL JOURNAL OF PHARMACEUTICS. - ISSN 0378-5173. - 487:1-2(2015), pp. 197-204. [10.1016/j.ijpharm.2015.04.003]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2787892
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