A novel approach for multivalent targeting by using gold nanoparticles noncovalently decorated by tight functionalization with a cone-glycocalixarene bearing four mannose units is reported. The targeting efficiency of these multivalent nanoparticles is shown to be remarkably improved compared to that of nanoparticles bearing a monovalent mannosylated derivative.
Gold nanoparticles decorated by clustered multivalent cone-glycocalixarenes actively improve the targeting efficiency toward cancer cells / Avvakumova, Svetlana; Fezzardi, Paola; Pandolfi, Laura; Colombo, Miriam; Sansone, Francesco; Casnati, Alessandro; Prosperi, Davide. - In: CHEMICAL COMMUNICATIONS. - ISSN 1359-7345. - 50:75(2014), pp. 11029-11032. [10.1039/C4CC03159H]