Late-onset Alzheimer's disease (AD) is heritable with 20 genes showing genome-wide association in the International Genomics of Alzheimer's Project (IGAP). To identify the biology underlying the disease, we extended these genetic data in a pathway analysis.

Convergent genetic and expression data implicate immunity in Alzheimer's disease / Jones L; Lambert JC; Wang LS; Choi SH; Harold D; Vedernikov A; Escott-Price V; Stone T; Richards A; Bellenguez C; Ibrahim-Verbaas CA; Naj AC; Sims R; Gerrish A; Jun G; DeStefano AL; Bis JC; Beecham GW; Grenier-Boley B; Russo G; Thornton-Wells TA; Jones N; Smith AV;Chouraki V; Thomas C; Ikram MA; Zelenika D; Vardarajan BN; Kamatani Y; Lin CF; Schmidt H; Kunkle BW; Dunstan ML; Ruiz A; Bihoreau MT;Reitz C; Pasquier F; Hollingworth P; Hanon O; Fitzpatrick AL; Buxbaum JD; Campion D; Crane PK; Becker T; Gudnason V; Cruchaga C; Craig D;Amin N; Berr C; Lopez OL; De Jager PL; Deramecourt V; Johnston JA; Evans D; Lovestone S; Letteneur L; Kornhuber J; Tárraga L; Rubinsztein DC; Eiriksdottir G; Sleegers K; Goate AM; Fiévet N; Huentelman MJ; Gill M; Emilsson V; Brown K; Kamboh MI; Keller L; Barberger-Gateau P;McGuinness B; Larson EB; Myers AJ; Dufouil C; Todd S; Wallon D; Love S; Kehoe P; Rogaeva E; Gallacher J; St George-Hyslop P; Clarimon J;Lleò A; Bayer A; Tsuang DW; Yu L; Tsolaki M; Bossù P; Spalletta G; Proitsi P; Collinge J; Sorbi S; Sanchez Garcia F; Fox N; Hardy J; Deniz Naranjo MC; Razquin C; Bosco P; Clarke R; Brayne C; Galimberti D; Mancuso M; Moebus S; Mecocci P; Del Zompo M; Maier W; Hampel H;Pilotto A; Bullido M; Panza F; Caffarra, Paolo; Nacmias B; Gilbert JR; Mayhaus M; Jessen F; Dichgans M; Lannfelt L; Hakonarson H; Pichler S;Carrasquillo MM; Ingelsson M; Beekly D; Alavarez V; Zou F; Valladares O; Younkin SG; Coto E; Hamilton-Nelson KL; Mateo I; Owen MJ; Faber KM; Jonsson PV; Combarros O; O'Donovan MC; Cantwell LB; Soininen H; Blacker D; Mead S; Mosley TH Jr; Bennett DA; Harris TB; Fratiglioni L; Holmes C; de Bruijn RF; Passmore P; Montine TJ; Bettens K; Rotter JI; Brice A; Morgan K; Foroud TM; Kukull WA; Hannequin D; Powell JF;Nalls MA; Ritchie K; Lunetta KL; Kauwe JS; Boerwinkle E; Riemenschneider M; Boada M; Hiltunen M; Martin ER; Pastor P; Schmidt R; Rujescu D; Dartigues JF; Mayeux R; Tzourio C; Hofman A; Nöthen MM; Graff C; Psaty BM; Haines JL; Lathrop M; Pericak-Vance MA; Launer LJ; Farrer LA; van Duijn CM; Van Broeckhoven C; Ramirez A; Schellenberg GD; Seshadri S; Amouyel P; Williams J; Holmans PA.. - In: ALZHEIMER'S & DEMENTIA. - ISSN 1552-5260. - 11:6(2015), pp. 658-671. [10.1016/j.jalz.2014.05.1757]

Convergent genetic and expression data implicate immunity in Alzheimer's disease

CAFFARRA, Paolo;
2015

Abstract

Late-onset Alzheimer's disease (AD) is heritable with 20 genes showing genome-wide association in the International Genomics of Alzheimer's Project (IGAP). To identify the biology underlying the disease, we extended these genetic data in a pathway analysis.
Convergent genetic and expression data implicate immunity in Alzheimer's disease / Jones L; Lambert JC; Wang LS; Choi SH; Harold D; Vedernikov A; Escott-Price V; Stone T; Richards A; Bellenguez C; Ibrahim-Verbaas CA; Naj AC; Sims R; Gerrish A; Jun G; DeStefano AL; Bis JC; Beecham GW; Grenier-Boley B; Russo G; Thornton-Wells TA; Jones N; Smith AV;Chouraki V; Thomas C; Ikram MA; Zelenika D; Vardarajan BN; Kamatani Y; Lin CF; Schmidt H; Kunkle BW; Dunstan ML; Ruiz A; Bihoreau MT;Reitz C; Pasquier F; Hollingworth P; Hanon O; Fitzpatrick AL; Buxbaum JD; Campion D; Crane PK; Becker T; Gudnason V; Cruchaga C; Craig D;Amin N; Berr C; Lopez OL; De Jager PL; Deramecourt V; Johnston JA; Evans D; Lovestone S; Letteneur L; Kornhuber J; Tárraga L; Rubinsztein DC; Eiriksdottir G; Sleegers K; Goate AM; Fiévet N; Huentelman MJ; Gill M; Emilsson V; Brown K; Kamboh MI; Keller L; Barberger-Gateau P;McGuinness B; Larson EB; Myers AJ; Dufouil C; Todd S; Wallon D; Love S; Kehoe P; Rogaeva E; Gallacher J; St George-Hyslop P; Clarimon J;Lleò A; Bayer A; Tsuang DW; Yu L; Tsolaki M; Bossù P; Spalletta G; Proitsi P; Collinge J; Sorbi S; Sanchez Garcia F; Fox N; Hardy J; Deniz Naranjo MC; Razquin C; Bosco P; Clarke R; Brayne C; Galimberti D; Mancuso M; Moebus S; Mecocci P; Del Zompo M; Maier W; Hampel H;Pilotto A; Bullido M; Panza F; Caffarra, Paolo; Nacmias B; Gilbert JR; Mayhaus M; Jessen F; Dichgans M; Lannfelt L; Hakonarson H; Pichler S;Carrasquillo MM; Ingelsson M; Beekly D; Alavarez V; Zou F; Valladares O; Younkin SG; Coto E; Hamilton-Nelson KL; Mateo I; Owen MJ; Faber KM; Jonsson PV; Combarros O; O'Donovan MC; Cantwell LB; Soininen H; Blacker D; Mead S; Mosley TH Jr; Bennett DA; Harris TB; Fratiglioni L; Holmes C; de Bruijn RF; Passmore P; Montine TJ; Bettens K; Rotter JI; Brice A; Morgan K; Foroud TM; Kukull WA; Hannequin D; Powell JF;Nalls MA; Ritchie K; Lunetta KL; Kauwe JS; Boerwinkle E; Riemenschneider M; Boada M; Hiltunen M; Martin ER; Pastor P; Schmidt R; Rujescu D; Dartigues JF; Mayeux R; Tzourio C; Hofman A; Nöthen MM; Graff C; Psaty BM; Haines JL; Lathrop M; Pericak-Vance MA; Launer LJ; Farrer LA; van Duijn CM; Van Broeckhoven C; Ramirez A; Schellenberg GD; Seshadri S; Amouyel P; Williams J; Holmans PA.. - In: ALZHEIMER'S & DEMENTIA. - ISSN 1552-5260. - 11:6(2015), pp. 658-671. [10.1016/j.jalz.2014.05.1757]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2785212
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