Convergent genetic and expression data implicate immunity in Alzheimer's disease

Jones, L; Lambert, Jc; Wang, Ls; Choi, Sh; Harold, D; Vedernikov, A; Escott Price, V; Stone, T; Richards, A; Bellenguez, C; Ibrahim Verbaas CA,; Naj, Ac; Sims, R; Gerrish, A; Jun, G; Destefano, Al; Bis, Jc; Beecham, Gw; Grenier Boley, B; Russo, G; Thornton Wells TA,; Jones, N; Smith, Av; Chouraki, V; Thomas, C; Ikram, Ma; Zelenika, D; Vardarajan, Bn; Kamatani, Y; Lin, Cf; Schmidt, H; Kunkle, Bw; Dunstan, Ml; Ruiz, A; Bihoreau, Mt; Reitz, C; Pasquier, F; Hollingworth, P; Hanon, O; Fitzpatrick, Al; Buxbaum, Jd; Campion, D; Crane, Pk; Becker, T; Gudnason, V; Cruchaga, C; Craig, D; Amin, N; Berr, C; Lopez, Ol; De Jager PL,; Deramecourt, V; Johnston, Ja; Evans, D; Lovestone, S; Letteneur, L; Kornhuber, J; Tárraga, L; Rubinsztein, Dc; Eiriksdottir, G; Sleegers, K; Goate, Am; Fiévet, N; Huentelman, Mj; Gill, M; Emilsson, V; Brown, K; Kamboh, Mi; Keller, L; Barberger Gateau, P; Mcguinness, B; Larson, Eb; Myers, Aj; Dufouil, C; Todd, S; Wallon, D; Love, S; Kehoe, P; Rogaeva, E; Gallacher, J; St George Hyslop, P; Clarimon, J; Lleò, A; Bayer, A; Tsuang, Dw; Yu, L; Tsolaki, M; Bossù, P; Spalletta, G; Proitsi, P; Collinge, J; Sorbi, S; Sanchez Garcia, F; Fox, N; Hardy, J; Deniz Naranjo MC,; Razquin, C; Bosco, P; Clarke, R; Brayne, C; Galimberti, D; Mancuso, M; Moebus, S; Mecocci, P; Del Zompo, M; Maier, W; Hampel, H; Pilotto, A; Bullido, M; Panza, F; Caffarra, Paolo; Nacmias, B; Gilbert, Jr; Mayhaus, M; Jessen, F; Dichgans, M; Lannfelt, L; Hakonarson, H; Pichler, S; Carrasquillo, Mm; Ingelsson, M; Beekly, D; Alavarez, V; Zou, F; Valladares, O; Younkin, Sg; Coto, E; Hamilton Nelson KL,; Mateo, I; Owen, Mj; Faber, Km; Jonsson, Pv; Combarros, O; O'Donovan, Mc; Cantwell, Lb; Soininen, H; Blacker, D; Mead, S; Mosley TH Jr,; Bennett, Da; Harris, Tb; Fratiglioni, L; Holmes, C; de Bruijn RF,; Passmore, P; Montine, Tj; Bettens, K; Rotter, Ji; Brice, A; Morgan, K; Foroud, Tm; Kukull, Wa; Hannequin, D; Powell, Jf; Nalls, Ma; Ritchie, K; Lunetta, Kl; Kauwe, Js; Boerwinkle, E; Riemenschneider, M; Boada, M; Hiltunen, M; Martin, Er; Pastor, P; Schmidt, R; Rujescu, D; Dartigues, Jf; Mayeux, R; Tzourio, C; Hofman, A; Nöthen, Mm; Graff, C; Psaty, Bm; Haines, Jl; Lathrop, M; Pericak Vance MA,; Launer, Lj; Farrer, La; van Duijn CM,; Van Broeckhoven, C; Ramirez, A; Schellenberg, Gd; Seshadri, S; Amouyel, P; Williams, J; Holmans, P. A.

doi:10.1016/j.jalz.2014.05.1757

Late-onset Alzheimer's disease (AD) is heritable with 20 genes showing genome-wide association in the International Genomics of Alzheimer's Project (IGAP). To identify the biology underlying the disease, we extended these genetic data in a pathway analysis.

Convergent genetic and expression data implicate immunity in Alzheimer's disease / Jones, L; Lambert, Jc; Wang, Ls; Choi, Sh; Harold, D; Vedernikov, A; Escott Price, V; Stone, T; Richards, A; Bellenguez, C; Ibrahim Verbaas, Ca; Naj, Ac; Sims, R; Gerrish, A; Jun, G; Destefano, Al; Bis, Jc; Beecham, Gw; Grenier Boley, B; Russo, G; Thornton Wells, Ta; Jones, N; Smith, Av; Chouraki, V; Thomas, C; Ikram, Ma; Zelenika, D; Vardarajan, Bn; Kamatani, Y; Lin, Cf; Schmidt, H; Kunkle, Bw; Dunstan, Ml; Ruiz, A; Bihoreau, Mt; Reitz, C; Pasquier, F; Hollingworth, P; Hanon, O; Fitzpatrick, Al; Buxbaum, Jd; Campion, D; Crane, Pk; Becker, T; Gudnason, V; Cruchaga, C; Craig, D; Amin, N; Berr, C; Lopez, Ol; De Jager, Pl; Deramecourt, V; Johnston, Ja; Evans, D; Lovestone, S; Letteneur, L; Kornhuber, J; Tárraga, L; Rubinsztein, Dc; Eiriksdottir, G; Sleegers, K; Goate, Am; Fiévet, N; Huentelman, Mj; Gill, M; Emilsson, V; Brown, K; Kamboh, Mi; Keller, L; Barberger Gateau, P; Mcguinness, B; Larson, Eb; Myers, Aj; Dufouil, C; Todd, S; Wallon, D; Love, S; Kehoe, P; Rogaeva, E; Gallacher, J; St George Hyslop, P; Clarimon, J; Lleò, A; Bayer, A; Tsuang, Dw; Yu, L; Tsolaki, M; Bossù, P; Spalletta, G; Proitsi, P; Collinge, J; Sorbi, S; Sanchez Garcia, F; Fox, N; Hardy, J; Deniz Naranjo, Mc; Razquin, C; Bosco, P; Clarke, R; Brayne, C; Galimberti, D; Mancuso, M; Moebus, S; Mecocci, P; Del Zompo, M; Maier, W; Hampel, H; Pilotto, A; Bullido, M; Panza, F; Caffarra, Paolo; Nacmias, B; Gilbert, Jr; Mayhaus, M; Jessen, F; Dichgans, M; Lannfelt, L; Hakonarson, H; Pichler, S; Carrasquillo, Mm; Ingelsson, M; Beekly, D; Alavarez, V; Zou, F; Valladares, O; Younkin, Sg; Coto, E; Hamilton Nelson, Kl; Mateo, I; Owen, Mj; Faber, Km; Jonsson, Pv; Combarros, O; O'Donovan, Mc; Cantwell, Lb; Soininen, H; Blacker, D; Mead, S; Mosley TH, Jr; Bennett, Da; Harris, Tb; Fratiglioni, L; Holmes, C; de Bruijn, Rf; Passmore, P; Montine, Tj; Bettens, K; Rotter, Ji; Brice, A; Morgan, K; Foroud, Tm; Kukull, Wa; Hannequin, D; Powell, Jf; Nalls, Ma; Ritchie, K; Lunetta, Kl; Kauwe, Js; Boerwinkle, E; Riemenschneider, M; Boada, M; Hiltunen, M; Martin, Er; Pastor, P; Schmidt, R; Rujescu, D; Dartigues, Jf; Mayeux, R; Tzourio, C; Hofman, A; Nöthen, Mm; Graff, C; Psaty, Bm; Haines, Jl; Lathrop, M; Pericak Vance, Ma; Launer, Lj; Farrer, La; van Duijn, Cm; Van Broeckhoven, C; Ramirez, A; Schellenberg, Gd; Seshadri, S; Amouyel, P; Williams, J; Holmans, P. A.. - In: ALZHEIMER'S & DEMENTIA. - ISSN 1552-5260. - 11:6(2015), pp. 658-671. [10.1016/j.jalz.2014.05.1757]