Si-CAE was measured in 16 composite marble industry workers furthermore, a spirometry was performed and 8oxoGua, 8oxoGuo 8oxodGuo, SP-A, SP-D, CC16 and HO-1 were dosed. A lower spirometric values (FEV1 and FVC) were observed among workers compared with controls and the following markers were increased: Si-CAE, 8oxoGuo and HO-1 expression. This study shows that exposure to silica can increase the levels of Si-CAE, which can be used to estimate the dose to the target. Finally, nonspecific spirometric abnormalities and an increase in biomarkers of effect were observed.
Biological monitoring and exposure to silica: Application of new dose and effect biomakers [Monitoraggio biologico ed esposizione a silice: Applicazione di nuovi indicatori di dose e d effetto] / Sabbadini, Francesco; Corradi, Massimo; Goldoni, Matteo; DE PALMA, Giuseppe; Gergelova', Petra; Toma, I. C; Andreoli, Roberta; Mozzoni, Paola; Pinelli, Silvana; Alinovi, Rossella; Apostoli, P; Mutti, Antonio. - In: GIORNALE ITALIANO DI MEDICINA DEL LAVORO ED ERGONOMIA. - ISSN 1592-7830. - 33:3 Suppl(2011), pp. 69-72.
Biological monitoring and exposure to silica: Application of new dose and effect biomakers [Monitoraggio biologico ed esposizione a silice: Applicazione di nuovi indicatori di dose e d effetto]
SABBADINI, Francesco;CORRADI, Massimo;GOLDONI, Matteo;DE PALMA, Giuseppe;GERGELOVA', Petra;ANDREOLI, Roberta;MOZZONI, Paola;PINELLI, Silvana;ALINOVI, Rossella;MUTTI, Antonio
2011-01-01
Abstract
Si-CAE was measured in 16 composite marble industry workers furthermore, a spirometry was performed and 8oxoGua, 8oxoGuo 8oxodGuo, SP-A, SP-D, CC16 and HO-1 were dosed. A lower spirometric values (FEV1 and FVC) were observed among workers compared with controls and the following markers were increased: Si-CAE, 8oxoGuo and HO-1 expression. This study shows that exposure to silica can increase the levels of Si-CAE, which can be used to estimate the dose to the target. Finally, nonspecific spirometric abnormalities and an increase in biomarkers of effect were observed.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
