The development of innovative nanosystems opens new perspectives for multidisciplinary applications at the frontier between materials science and nanomedicine. Here we present a novel hybrid nanosystem based on cytocompatible inorganic SiC/SiOx core/shell nanowires conjugated via click-chemistry procedures with an organic photosensitizer, a tetracarboxyphenyl porphyrin derivative. We show that this nanosystem is an efficient source of singlet oxygen for cell oxidative stress when irradiated with 6 MV X-Rays at low doses (0.4-2 Gy). The in-vitro clonogenic survival assay on lung adenocarcinoma cells shows that 12 days after irradiation at a dose of 2 Gy, the cell population is reduced by about 75% with respect to control cells. These results demonstrate that our approach is very efficient to enhance radiation therapy effects for cancer treatments.
Porphyrin conjugated SiC/SiOx nanowires for X-ray-excited photodynamic therapy / Rossi, F., Bedogni, E., Bigi, F., Rimoldi, T., Cristofolini, L., Pinelli, S., Alinovi, R., Negri, M., Dhanabalan, S.C., Attolini, G., Fabbri, F., Goldoni, M., Mutti, A., Benecchi, G., Ghetti, C., Iannotta, S., Salviati, G.. - In: SCIENTIFIC REPORTS. - ISSN 2045-2322. - 5:(2015), p. 7606. [10.1038/srep07606]
Porphyrin conjugated SiC/SiOx nanowires for X-ray-excited photodynamic therapy
ROSSI, Francesca;BEDOGNI, Elena;BIGI, Franca;RIMOLDI, Tiziano;CRISTOFOLINI, Luigi;PINELLI, Silvana;ALINOVI, Rossella;NEGRI, Marco;GOLDONI, Matteo;MUTTI, Antonio;
2015-01-01
Abstract
The development of innovative nanosystems opens new perspectives for multidisciplinary applications at the frontier between materials science and nanomedicine. Here we present a novel hybrid nanosystem based on cytocompatible inorganic SiC/SiOx core/shell nanowires conjugated via click-chemistry procedures with an organic photosensitizer, a tetracarboxyphenyl porphyrin derivative. We show that this nanosystem is an efficient source of singlet oxygen for cell oxidative stress when irradiated with 6 MV X-Rays at low doses (0.4-2 Gy). The in-vitro clonogenic survival assay on lung adenocarcinoma cells shows that 12 days after irradiation at a dose of 2 Gy, the cell population is reduced by about 75% with respect to control cells. These results demonstrate that our approach is very efficient to enhance radiation therapy effects for cancer treatments.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
