The development of innovative nanosystems opens new perspectives for multidisciplinary applications at the frontier between materials science and nanomedicine. Here we present a novel hybrid nanosystem based on cytocompatible inorganic SiC/SiOx core/shell nanowires conjugated via click-chemistry procedures with an organic photosensitizer, a tetracarboxyphenyl porphyrin derivative. We show that this nanosystem is an efficient source of singlet oxygen for cell oxidative stress when irradiated with 6 MV X-Rays at low doses (0.4-2 Gy). The in-vitro clonogenic survival assay on lung adenocarcinoma cells shows that 12 days after irradiation at a dose of 2 Gy, the cell population is reduced by about 75% with respect to control cells. These results demonstrate that our approach is very efficient to enhance radiation therapy effects for cancer treatments.

Porphyrin conjugated SiC/SiOx nanowires for X-ray-excited photodynamic therapy / Rossi, Francesca; Bedogni, Elena; Bigi, Franca; Rimoldi, Tiziano; Cristofolini, Luigi; Pinelli, Silvana; Alinovi, Rossella; Negri, Marco; Dhanabalan, S. C; Attolini, G; Fabbri, F; Goldoni, Matteo; Mutti, Antonio; Benecchi, G; Ghetti, C; Iannotta, S; Salviati, G.. - In: SCIENTIFIC REPORTS. - ISSN 2045-2322. - 5:(2015), p. 7606. [10.1038/srep07606]

Porphyrin conjugated SiC/SiOx nanowires for X-ray-excited photodynamic therapy

ROSSI, Francesca;BEDOGNI, Elena;BIGI, Franca;RIMOLDI, Tiziano;CRISTOFOLINI, Luigi;PINELLI, Silvana;ALINOVI, Rossella;NEGRI, Marco;GOLDONI, Matteo;MUTTI, Antonio;
2015

Abstract

The development of innovative nanosystems opens new perspectives for multidisciplinary applications at the frontier between materials science and nanomedicine. Here we present a novel hybrid nanosystem based on cytocompatible inorganic SiC/SiOx core/shell nanowires conjugated via click-chemistry procedures with an organic photosensitizer, a tetracarboxyphenyl porphyrin derivative. We show that this nanosystem is an efficient source of singlet oxygen for cell oxidative stress when irradiated with 6 MV X-Rays at low doses (0.4-2 Gy). The in-vitro clonogenic survival assay on lung adenocarcinoma cells shows that 12 days after irradiation at a dose of 2 Gy, the cell population is reduced by about 75% with respect to control cells. These results demonstrate that our approach is very efficient to enhance radiation therapy effects for cancer treatments.
Porphyrin conjugated SiC/SiOx nanowires for X-ray-excited photodynamic therapy / Rossi, Francesca; Bedogni, Elena; Bigi, Franca; Rimoldi, Tiziano; Cristofolini, Luigi; Pinelli, Silvana; Alinovi, Rossella; Negri, Marco; Dhanabalan, S. C; Attolini, G; Fabbri, F; Goldoni, Matteo; Mutti, Antonio; Benecchi, G; Ghetti, C; Iannotta, S; Salviati, G.. - In: SCIENTIFIC REPORTS. - ISSN 2045-2322. - 5:(2015), p. 7606. [10.1038/srep07606]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2784008
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 56
  • ???jsp.display-item.citation.isi??? 51
social impact