OBJECTIVE: To assess the association between adiposity indexes (body mass index [BMI], fat mass, adipocyte size) and circulating inflammation markers with known metabolic relevance or insulin sensitivity in overweight/obese children. STUDY DESIGN: Twenty-eight children (males/females: 13/15) with different degrees of overweight (BMI z-score: 1.64-3.1; fat mass: 14.1-49.8 kg) were studied. BMI, body composition (dual-energy x-ray absorptiometry scanning), subcutaneous adipocyte diameter (needle biopsy of subcutaneous abdominal fat), blood tumor necrosis factor-alpha and interleukin-6 concentrations and insulin sensitivity (frequently sampled intravenous glucose tolerance test) were assessed. RESULTS: Adipocyte diameter, more than BMI and fat mass, was significantly associated with interleukin-6 (r = 0.62, P < .001) and tumor necrosis factor-alpha (r = 0.61, P < .001). Moreover adipocyte size was associated with insulin sensitivity (R2 = 0.15, F = 4.69, P = .04) independently from fat mass. CONCLUSIONS: Adipocyte size is a factor linked to both inflammation and insulin resistance in overweight/obese children. This is similar to the findings in adults and lends support to the tenet that the earlier obesity ensues, the more severe the biologic consequences may be.

Fat cell size, insulin sensitivity, and inflammation in obese children / Claudio, Maffeis; Davide, Silvagni; Bonadonna, Riccardo; Alessandra, Grezzani; Claudia, Banzato; Luciano, Tatò. - In: THE JOURNAL OF PEDIATRICS. - ISSN 0022-3476. - 151:6(2007), pp. 647-652. [10.1016/j.jpeds.2007.04.053]

Fat cell size, insulin sensitivity, and inflammation in obese children.

BONADONNA, Riccardo;
2007-01-01

Abstract

OBJECTIVE: To assess the association between adiposity indexes (body mass index [BMI], fat mass, adipocyte size) and circulating inflammation markers with known metabolic relevance or insulin sensitivity in overweight/obese children. STUDY DESIGN: Twenty-eight children (males/females: 13/15) with different degrees of overweight (BMI z-score: 1.64-3.1; fat mass: 14.1-49.8 kg) were studied. BMI, body composition (dual-energy x-ray absorptiometry scanning), subcutaneous adipocyte diameter (needle biopsy of subcutaneous abdominal fat), blood tumor necrosis factor-alpha and interleukin-6 concentrations and insulin sensitivity (frequently sampled intravenous glucose tolerance test) were assessed. RESULTS: Adipocyte diameter, more than BMI and fat mass, was significantly associated with interleukin-6 (r = 0.62, P < .001) and tumor necrosis factor-alpha (r = 0.61, P < .001). Moreover adipocyte size was associated with insulin sensitivity (R2 = 0.15, F = 4.69, P = .04) independently from fat mass. CONCLUSIONS: Adipocyte size is a factor linked to both inflammation and insulin resistance in overweight/obese children. This is similar to the findings in adults and lends support to the tenet that the earlier obesity ensues, the more severe the biologic consequences may be.
2007
Fat cell size, insulin sensitivity, and inflammation in obese children / Claudio, Maffeis; Davide, Silvagni; Bonadonna, Riccardo; Alessandra, Grezzani; Claudia, Banzato; Luciano, Tatò. - In: THE JOURNAL OF PEDIATRICS. - ISSN 0022-3476. - 151:6(2007), pp. 647-652. [10.1016/j.jpeds.2007.04.053]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2762593
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