Objective: During the male aging process, testosterone (T) levels progressively fall and inflammatory biomarkers increase. Although a relationship between these 2 phenomena has been tested in previous clinical trials, there is inconclusive evidence about the potential anti-inflammatory action of T. Methods: A total of 108 healthy males >65 years with serum T concentration <475 ng/dL were recruited by direct mailings to alumni of the University of Pennsylvania and Temple University and randomized to 60-cm(2) T or a placebo patch for 36 months. Ninety-six subjects completed the trial. Information and stored serum specimens from this trial were used to test the hypothesis of the inhibitory effect of T on inflammation. We evaluated 70 males (42 in the T group) who had banked specimens from multiple time points available for assays of T, C-reactive protein (CRP), tumor necrosis factor (TNF)-alpha, soluble TNF-alpha receptor-1 (TNFR1), interleukin-6 (IL-6), and soluble IL-6 receptors (sIL6r and sgp130). Results: The mean age +/- SD at baseline was 71.8 +/- 4.9 years. Testosterone replacement therapy for 36 months did not induce significant decreases in inflammatory markers. A trend toward a significant increase was observed in the placebo group for TNF-alpha (P = .03) and sgp130 (P = .01). Significant differences in estimated means of TNFR1 (but not other inflammatory markers), with lower levels in the T group, were observed at the 36-month time point. In T-treated subjects we found an almost significant treatment x time interaction term TNFR1 (P = .02) independent of total body fat content as assessed by dual energy X-ray absorptiometry (DXA). No serious adverse effect was observed. Conclusions: Transdermal T treatment of older males for 36 months is not associated with significant changes in inflammatory markers.

Effects of Transdermal Testosterone Treatment on Inflammatory Markers in Elderly Men / Maggio, Marcello Giuseppe; Snyder, Pj; DE VITA, Francesca; Ceda, Gian Paolo; Milaneschi, Y; Lauretani, F; Luci, M; Cattabiani, C; Peachey, H; Valenti, G; Cappola, Ar; Longo, Dl; Ferrucci, L.. - In: ENDOCRINE PRACTICE. - ISSN 1530-891X. - 20:11(2014), pp. 1170-1177. [10.4158/EP13357.OR]

Effects of Transdermal Testosterone Treatment on Inflammatory Markers in Elderly Men.

MAGGIO, Marcello Giuseppe;DE VITA, FRANCESCA;CEDA, Gian Paolo;Lauretani F;
2014

Abstract

Objective: During the male aging process, testosterone (T) levels progressively fall and inflammatory biomarkers increase. Although a relationship between these 2 phenomena has been tested in previous clinical trials, there is inconclusive evidence about the potential anti-inflammatory action of T. Methods: A total of 108 healthy males >65 years with serum T concentration <475 ng/dL were recruited by direct mailings to alumni of the University of Pennsylvania and Temple University and randomized to 60-cm(2) T or a placebo patch for 36 months. Ninety-six subjects completed the trial. Information and stored serum specimens from this trial were used to test the hypothesis of the inhibitory effect of T on inflammation. We evaluated 70 males (42 in the T group) who had banked specimens from multiple time points available for assays of T, C-reactive protein (CRP), tumor necrosis factor (TNF)-alpha, soluble TNF-alpha receptor-1 (TNFR1), interleukin-6 (IL-6), and soluble IL-6 receptors (sIL6r and sgp130). Results: The mean age +/- SD at baseline was 71.8 +/- 4.9 years. Testosterone replacement therapy for 36 months did not induce significant decreases in inflammatory markers. A trend toward a significant increase was observed in the placebo group for TNF-alpha (P = .03) and sgp130 (P = .01). Significant differences in estimated means of TNFR1 (but not other inflammatory markers), with lower levels in the T group, were observed at the 36-month time point. In T-treated subjects we found an almost significant treatment x time interaction term TNFR1 (P = .02) independent of total body fat content as assessed by dual energy X-ray absorptiometry (DXA). No serious adverse effect was observed. Conclusions: Transdermal T treatment of older males for 36 months is not associated with significant changes in inflammatory markers.
Effects of Transdermal Testosterone Treatment on Inflammatory Markers in Elderly Men / Maggio, Marcello Giuseppe; Snyder, Pj; DE VITA, Francesca; Ceda, Gian Paolo; Milaneschi, Y; Lauretani, F; Luci, M; Cattabiani, C; Peachey, H; Valenti, G; Cappola, Ar; Longo, Dl; Ferrucci, L.. - In: ENDOCRINE PRACTICE. - ISSN 1530-891X. - 20:11(2014), pp. 1170-1177. [10.4158/EP13357.OR]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2762143
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