Three square-planar complexes of nickel(II) with the tridentate condensation derivative of 2-(diphenylphosphino)benzaldehyde and ethyl carbazate, and monodentate pseudohalides, have been synthesized. Their crystal structures have been determined. All the complexes showed a significant antifungal activity, while only the azido complex displayed antibacterial activity. All the complexes were cytotoxic to a panel of six tumor cell lines, the azido complex showing a similar activity as cisplatin to leukemia cell line K562 and lower toxicity to normal MRC-5 cells than that anticancer agent. The complexes interfered with cell cycle of tumor cells and induced plasmid DNA cleavage

Synthesis, characterization and biological activity of three square-planar complexes of Ni(II) with ethyl (2E)-2-[2-(diphenylphosphino)benzylidene]hydrazinecarboxylate and monodentate pseudohalides / Milica, Milenković; Bacchi, Alessia; Giulia, Cantoni; Jovana, Vilipić; Dušan, Sladić; Miroslava, Vujčić; Nevenka, Gligorijević; Katarina, Jovanović; Siniša, Radulović; Katarina, Anđelković. - In: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. - ISSN 0223-5234. - 68:(2013), pp. 111-120. [10.1016/j.ejmech.2013.07.039]

Synthesis, characterization and biological activity of three square-planar complexes of Ni(II) with ethyl (2E)-2-[2-(diphenylphosphino)benzylidene]hydrazinecarboxylate and monodentate pseudohalides

BACCHI, Alessia;
2013-01-01

Abstract

Three square-planar complexes of nickel(II) with the tridentate condensation derivative of 2-(diphenylphosphino)benzaldehyde and ethyl carbazate, and monodentate pseudohalides, have been synthesized. Their crystal structures have been determined. All the complexes showed a significant antifungal activity, while only the azido complex displayed antibacterial activity. All the complexes were cytotoxic to a panel of six tumor cell lines, the azido complex showing a similar activity as cisplatin to leukemia cell line K562 and lower toxicity to normal MRC-5 cells than that anticancer agent. The complexes interfered with cell cycle of tumor cells and induced plasmid DNA cleavage
2013
Synthesis, characterization and biological activity of three square-planar complexes of Ni(II) with ethyl (2E)-2-[2-(diphenylphosphino)benzylidene]hydrazinecarboxylate and monodentate pseudohalides / Milica, Milenković; Bacchi, Alessia; Giulia, Cantoni; Jovana, Vilipić; Dušan, Sladić; Miroslava, Vujčić; Nevenka, Gligorijević; Katarina, Jovanović; Siniša, Radulović; Katarina, Anđelković. - In: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. - ISSN 0223-5234. - 68:(2013), pp. 111-120. [10.1016/j.ejmech.2013.07.039]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2761704
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