Bifidobacteria constitute a specific group of commensal bacteria that inhabit the gastrointestinal tracts of humans and other mammals. Bifidobacterium breve UCC2003 has previously been shown to utilize several plant-derived carbohydrates that include cellodextrins, starch, and galactan. In the present study, we investigated the ability of this strain to utilize the mucin- and human milk oligosaccharide (HMO)-derived carbohydrate sialic acid. Using a combination of transcriptomic and functional genomic approaches, we identified a gene cluster dedicated to the uptake and metabolism of sialic acid. Furthermore, we demonstrate that B. breve UCC2003 can cross feed on sialic acid derived from the metabolism of 3'-sialyllactose, an abundant HMO, by another infant gut bifidobacterial strain, Bifidobacterium bifidum PRL2010

Metabolism of sialic acid by Bifidobacterium breve UCC2003 / Murin, Egan; Mary O'Connell, Motherway; Ventura, Marco; Douwe van, Sinderen. - In: APPLIED AND ENVIRONMENTAL MICROBIOLOGY. - ISSN 1098-5336. - 80:(2014), pp. 4414-4426. [10.1128/AEM.01114-14]

Metabolism of sialic acid by Bifidobacterium breve UCC2003

VENTURA, Marco;
2014-01-01

Abstract

Bifidobacteria constitute a specific group of commensal bacteria that inhabit the gastrointestinal tracts of humans and other mammals. Bifidobacterium breve UCC2003 has previously been shown to utilize several plant-derived carbohydrates that include cellodextrins, starch, and galactan. In the present study, we investigated the ability of this strain to utilize the mucin- and human milk oligosaccharide (HMO)-derived carbohydrate sialic acid. Using a combination of transcriptomic and functional genomic approaches, we identified a gene cluster dedicated to the uptake and metabolism of sialic acid. Furthermore, we demonstrate that B. breve UCC2003 can cross feed on sialic acid derived from the metabolism of 3'-sialyllactose, an abundant HMO, by another infant gut bifidobacterial strain, Bifidobacterium bifidum PRL2010
Metabolism of sialic acid by Bifidobacterium breve UCC2003 / Murin, Egan; Mary O'Connell, Motherway; Ventura, Marco; Douwe van, Sinderen. - In: APPLIED AND ENVIRONMENTAL MICROBIOLOGY. - ISSN 1098-5336. - 80:(2014), pp. 4414-4426. [10.1128/AEM.01114-14]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2761117
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 100
  • ???jsp.display-item.citation.isi??? 100
social impact