The 1,4- and 1,6-Addition of Vinylogous Donor Systems in on-Water and Organocatalyzed Reactions

The vinylogy principle, which explains the transmission of the electronic effects through a conjugated system, has increasingly attracted the curiosity of organic chemists while challenging their abilities. The design of new synthetic methodologies based on the application of this principle experienced an exponential growth in the past few years, especially when this topic was connected to other emerging fields such as eco-friendly synthetic methods or enantioselective catalysis. In this brief contribution we will present how the vinylogy principle was applied to on-water vinylogous Michael additions of pyrrole-based dienolates to diazadiene acceptors and to organocatalyzed 1,6-addition of vinylogous lactones to 2,4-dienals.