Allergenicity assessment of genetically modified (GM) plants is one of the key pillars in the safety assessment process of these products. As part of this evaluation, one of the concerns is to assess that unintended effects (e.g. over-expression of endogenous allergens) relevant for the food safety have not occurred due to the genetic modification. Novel technologies are now available and could be used as complementary and/or alternative methods to those based on human sera for the assessment of endogenous allergenicity. In view of these developments and as a step forward in the allergenicity assessment of GM plants, it is recommended that known endogenous allergens are included in the compositional analysis as additional parameters to be measured.
Endogenous allergens and compositional analysis in the allergenicity assessment of genetically modified plants / A., Fernandez; E. N. C., Mills; M., Lovik; A., Spoek; Germini, Andrea; A., Mikalsen; J. M., Wal. - In: FOOD AND CHEMICAL TOXICOLOGY. - ISSN 0278-6915. - 62:December 2013(2013), pp. 1-6. [10.1016/j.fct.2013.08.023]
Endogenous allergens and compositional analysis in the allergenicity assessment of genetically modified plants.
GERMINI, Andrea;
2013-01-01
Abstract
Allergenicity assessment of genetically modified (GM) plants is one of the key pillars in the safety assessment process of these products. As part of this evaluation, one of the concerns is to assess that unintended effects (e.g. over-expression of endogenous allergens) relevant for the food safety have not occurred due to the genetic modification. Novel technologies are now available and could be used as complementary and/or alternative methods to those based on human sera for the assessment of endogenous allergenicity. In view of these developments and as a step forward in the allergenicity assessment of GM plants, it is recommended that known endogenous allergens are included in the compositional analysis as additional parameters to be measured.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
