It has recently been reported that dogs affected by canine heartworm disease (Dirofilaria immitis) can show an increase in plasma levels of myoglobin and cardiac troponin I, two markers of muscle/myocardial injury. In order to determine if this increase is due to myocardial damage, the right ventricle of 24 naturally infected dogs was examined by routine histology and immunohistochemistry with anti-myoglobin and anti-cardiac troponin I antibodies. Microscopic lesions included necrosis and myocyte vacuolization, and were associated with loss of staining for one or both proteins. Results confirm that increased levels of myoglobin and cardiac troponin I are indicative of myocardial damage in dogs affected by heartworm disease

Myocardial damage in dogs affected by heartworm disease (Dirofilaria immitis): immunohistochemical study of cardiac myoglobin and troponin I in naturally infected dogs / Carretón, E; Grandi, Giulio; Morchón, R; Simón, F; Passeri, Benedetta; Cantoni, Anna Maria; Kramer, Laura Helen; Montoya Alonso, J. A.. - In: VETERINARY PARASITOLOGY. - ISSN 0304-4017. - 189:2-4(2012), pp. 390-393. [10.1016/j.vetpar.2012.04.013]

Myocardial damage in dogs affected by heartworm disease (Dirofilaria immitis): immunohistochemical study of cardiac myoglobin and troponin I in naturally infected dogs

GRANDI, Giulio;PASSERI, Benedetta;CANTONI, Anna Maria;KRAMER, Laura Helen;
2012

Abstract

It has recently been reported that dogs affected by canine heartworm disease (Dirofilaria immitis) can show an increase in plasma levels of myoglobin and cardiac troponin I, two markers of muscle/myocardial injury. In order to determine if this increase is due to myocardial damage, the right ventricle of 24 naturally infected dogs was examined by routine histology and immunohistochemistry with anti-myoglobin and anti-cardiac troponin I antibodies. Microscopic lesions included necrosis and myocyte vacuolization, and were associated with loss of staining for one or both proteins. Results confirm that increased levels of myoglobin and cardiac troponin I are indicative of myocardial damage in dogs affected by heartworm disease
Myocardial damage in dogs affected by heartworm disease (Dirofilaria immitis): immunohistochemical study of cardiac myoglobin and troponin I in naturally infected dogs / Carretón, E; Grandi, Giulio; Morchón, R; Simón, F; Passeri, Benedetta; Cantoni, Anna Maria; Kramer, Laura Helen; Montoya Alonso, J. A.. - In: VETERINARY PARASITOLOGY. - ISSN 0304-4017. - 189:2-4(2012), pp. 390-393. [10.1016/j.vetpar.2012.04.013]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11381/2712495
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