BACKGROUND: Adenoid cystic carcinoma (ACC) is a locally aggressive tumor with a high prevalence of distant metastases. The purpose of this study was to identify independent predictors of outcome and to characterize the patterns of failure. METHODS: An international retrospective review was conducted of 489 patients with ACC treated between 1985 and 2011 in 9 cancer centers worldwide. RESULTS: Five-year overall-survival (OS), disease-specific survival (DSS), and disease-free survival (DFS) were 76%, 80%, and 68%, respectively. Independent predictors of OS and DSS were: age, site, N classification, and presence of distant metastases. N classification, age, and bone invasion were associated with DFS on multivariate analysis. Age, tumor site, orbital invasion, and N classification were independent predictors of distant metastases. CONCLUSION: The clinical course of ACC is slow but persistent. Paranasal sinus origin is associated with the lowest distant metastases rate but with the poorest outcome. These prognostic estimates should be considered when tailoring treatment for patients with ACC. © 2013 Wiley Periodicals, Inc. Head Neck, 2013.
Analysis of failure in patients with adenoid cystic carcinoma of the head and neck. An international collaborative study / Moran Amit;Yoav Binenbaum;Kanika Sharma;Naomi Ramer;Ilana Ramer;Abib Agbetoba;Brett Miles;Xinjie Yang;Delin Lei;Kristine Bjøerndal;Christian Godballe;Thomas Mücke;Klaus-Dietrich Wolff;Dan Fliss;André M. Eckardt;Chiara Copelli;Enrico Sesenna;Frank Palmer;Snehal Patel;Ziv Gil. - In: HEAD & NECK. - ISSN 1043-3074. - 36:(7)(2014), pp. 998-1004. [10.1002/hed.23405]
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