Chronic obstructive pulmonary disease (COPD) is a common disease characterized by airflow obstruction and lung hyperinflation leading to dyspnea and exercise capacity limitation. Objectives: The present study was designed to evaluate whether an extra-fine combination of beclomethasone and formoterol (BDP/F) was effective in reducing air trapping in COPD patients with hyperinflation. Fluticasone salmeterol (FP/S) combination treatment was the active control. Methods: COPD patients with forced expiratory volume in one second ,65% and plethysmographic functional residual capacity $120% of predicted were randomized to a doubleblind, double-dummy, 12-week, parallel group, treatment with either BDP/F 400/24 μg/day or FP/S 500/100 μg/day. Lung volumes were measured with full body plethysmography, and dyspnea was measured with transition dyspnea index.

Effects of beclomethasone/formoterol fixed combination on lung hyperinflation and dyspnea in COPD patients / Tzani, Panagiota; Crisafulli, Ernesto; Nicolini, G; Aiello, Marina; Chetta, Alfredo Antonio; Clini, Em; Olivieri, Dario. - In: INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE. - ISSN 1176-9106. - 6:1(2011), pp. 503-509. [10.2147/COPD.S23746]

Effects of beclomethasone/formoterol fixed combination on lung hyperinflation and dyspnea in COPD patients.

TZANI, Panagiota;CRISAFULLI, Ernesto;AIELLO, Marina;CHETTA, Alfredo Antonio;OLIVIERI, Dario
2011-01-01

Abstract

Chronic obstructive pulmonary disease (COPD) is a common disease characterized by airflow obstruction and lung hyperinflation leading to dyspnea and exercise capacity limitation. Objectives: The present study was designed to evaluate whether an extra-fine combination of beclomethasone and formoterol (BDP/F) was effective in reducing air trapping in COPD patients with hyperinflation. Fluticasone salmeterol (FP/S) combination treatment was the active control. Methods: COPD patients with forced expiratory volume in one second ,65% and plethysmographic functional residual capacity $120% of predicted were randomized to a doubleblind, double-dummy, 12-week, parallel group, treatment with either BDP/F 400/24 μg/day or FP/S 500/100 μg/day. Lung volumes were measured with full body plethysmography, and dyspnea was measured with transition dyspnea index.
2011
Effects of beclomethasone/formoterol fixed combination on lung hyperinflation and dyspnea in COPD patients / Tzani, Panagiota; Crisafulli, Ernesto; Nicolini, G; Aiello, Marina; Chetta, Alfredo Antonio; Clini, Em; Olivieri, Dario. - In: INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE. - ISSN 1176-9106. - 6:1(2011), pp. 503-509. [10.2147/COPD.S23746]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2711504
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