Patients with congestive heart failure or COPD may share an increased response in minute ventilation (V˙ E) to carbon dioxide output (V˙ CO2) during exercise. The goal of this study was to ascertain whether the V˙ E/V˙ CO2 slope and V˙ E/V˙ CO2 intercept can discriminate between subjects with congestive heart failure and those with COPD at equal peak oxygen uptake (V˙ O2). METHODS: We studied 46 subjects with congestive heart failure (mean age 61 9 y) and 46 subjects withCOPD(mean age 648 y) who performed a cardiopulmonary exercise test. RESULTS: TheV˙ E/V˙ CO2 slope was significantly higher in subjects with congestive heart failure compared with those with COPD (39.5 9.5 vs 31.8 7.4, P < .01) at peak V˙ O2 < 16 mL/kg/min, but not > 16 mL/kg/min (28.3 5.3 vs 28.9 6.6). TheV˙ E/V˙ CO2 intercept was significantly higher in both subgroups of subjects with COPD compared with the corresponding values in the subjects with congestive heart failure (3.60 1.7 vs 0.16 1.7 L/min, P < .01; 3.63 2.7 vs 0.87 1.5 L/min, P < .01). According to receiver operating characteristic curve analysis, when all subjects with peak V˙ O2 < 16 mL/kg/min were considered, subjects with COPD had a higher likelihood to have the V˙ E/V˙ CO2 intercept > 2.14 L/min (0.92 sensitivity, 0.96 specificity). Regardless of peak V˙ O2, the end-tidal pressure of CO2 (PETCO2) at peak exercise was not different in subjects with congestive heart failure (P .42) and was significantly higher in subjects with COPD (P < .01) compared with the corresponding unloaded PETCO2. CONCLUSIONS: The ventilatory response toV˙ CO2 during exercise was significantly different between subjects with congestive heart failure and those with COPD in terms of the V˙ E/V˙ CO2 slope with moderate-to-severe reduction in exercise capacity and in terms of theV˙ E/V˙ CO2 intercept regardless of exercise capacity. Key words: congestive heart failure; COPD; exercise; ventilatory response.

Ventilatory Response to Carbon Dioxide Output in Subjects with Congestive Heart Failure and in Patients with COPD with Comparable Exercise Capacity / Teopompi, Elisabetta; Tzani, Panagiota; Aiello, Marina; Ramponi, Sara; Visca, D; Gioia, Mr; Marangio, Emilio; Serra, W; Chetta, Alfredo Antonio. - In: RESPIRATORY CARE. - ISSN 0020-1324. - 59:7(2014), pp. 1034-1041. [10.4187/respcare.02629]

Ventilatory Response to Carbon Dioxide Output in Subjects with Congestive Heart Failure and in Patients with COPD with Comparable Exercise Capacity.

TEOPOMPI, Elisabetta;TZANI, Panagiota;AIELLO, Marina;RAMPONI, Sara;MARANGIO, Emilio;CHETTA, Alfredo Antonio
2014-01-01

Abstract

Patients with congestive heart failure or COPD may share an increased response in minute ventilation (V˙ E) to carbon dioxide output (V˙ CO2) during exercise. The goal of this study was to ascertain whether the V˙ E/V˙ CO2 slope and V˙ E/V˙ CO2 intercept can discriminate between subjects with congestive heart failure and those with COPD at equal peak oxygen uptake (V˙ O2). METHODS: We studied 46 subjects with congestive heart failure (mean age 61 9 y) and 46 subjects withCOPD(mean age 648 y) who performed a cardiopulmonary exercise test. RESULTS: TheV˙ E/V˙ CO2 slope was significantly higher in subjects with congestive heart failure compared with those with COPD (39.5 9.5 vs 31.8 7.4, P < .01) at peak V˙ O2 < 16 mL/kg/min, but not > 16 mL/kg/min (28.3 5.3 vs 28.9 6.6). TheV˙ E/V˙ CO2 intercept was significantly higher in both subgroups of subjects with COPD compared with the corresponding values in the subjects with congestive heart failure (3.60 1.7 vs 0.16 1.7 L/min, P < .01; 3.63 2.7 vs 0.87 1.5 L/min, P < .01). According to receiver operating characteristic curve analysis, when all subjects with peak V˙ O2 < 16 mL/kg/min were considered, subjects with COPD had a higher likelihood to have the V˙ E/V˙ CO2 intercept > 2.14 L/min (0.92 sensitivity, 0.96 specificity). Regardless of peak V˙ O2, the end-tidal pressure of CO2 (PETCO2) at peak exercise was not different in subjects with congestive heart failure (P .42) and was significantly higher in subjects with COPD (P < .01) compared with the corresponding unloaded PETCO2. CONCLUSIONS: The ventilatory response toV˙ CO2 during exercise was significantly different between subjects with congestive heart failure and those with COPD in terms of the V˙ E/V˙ CO2 slope with moderate-to-severe reduction in exercise capacity and in terms of theV˙ E/V˙ CO2 intercept regardless of exercise capacity. Key words: congestive heart failure; COPD; exercise; ventilatory response.
2014
Ventilatory Response to Carbon Dioxide Output in Subjects with Congestive Heart Failure and in Patients with COPD with Comparable Exercise Capacity / Teopompi, Elisabetta; Tzani, Panagiota; Aiello, Marina; Ramponi, Sara; Visca, D; Gioia, Mr; Marangio, Emilio; Serra, W; Chetta, Alfredo Antonio. - In: RESPIRATORY CARE. - ISSN 0020-1324. - 59:7(2014), pp. 1034-1041. [10.4187/respcare.02629]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2710296
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