We report the effects of K:D-Rib, a D-ribose and KHCO3 water solution on HTB-126 human cancer cell line proliferation and the preliminary ultraviolet-visible (UV-VIS) measures of DNAzyme as biosensor of extracellular K+ concentration. On the one hand, we demonstrate that the synergic action of KHCO3 and D-ribose from one side has a cytostatic effect on human breast cancer cell line increasing by 30% the doubling population time of treated cells with respect to the control; and on the other hand we demonstrate how it seems to permit the K+ uptake.
K:D-Rib: cancer cell proliferation inibitor and DNAzyme folding promoter / L., Bruni; Croci, Simonetta. - In: JOURNAL OF BIOLOGICAL RESEARCH. - ISSN 1826-8838. - 87:1(2014), p. 2135. [10.4081/jbr.2014.2135]
K:D-Rib: cancer cell proliferation inibitor and DNAzyme folding promoter
CROCI, Simonetta
2014-01-01
Abstract
We report the effects of K:D-Rib, a D-ribose and KHCO3 water solution on HTB-126 human cancer cell line proliferation and the preliminary ultraviolet-visible (UV-VIS) measures of DNAzyme as biosensor of extracellular K+ concentration. On the one hand, we demonstrate that the synergic action of KHCO3 and D-ribose from one side has a cytostatic effect on human breast cancer cell line increasing by 30% the doubling population time of treated cells with respect to the control; and on the other hand we demonstrate how it seems to permit the K+ uptake.| File | Dimensione | Formato | |
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