Lung cancer is a major cause of death in Western countries. Current screening methods are invasive and still lead to a high percentage of false positives. There is, therefore, a need to find biomarkers that increase the probability of detecting lung cancer early. MicroRNAs (miRNAs) are stable molecules in blood plasma and exhaled breath condensate (EBC). We quantified miRNA-21 and miRNA-486 expression from plasma and EBC samples from patients with a diagnosis of non-small-cell lung cancer (NSCLC) and controls. miRNA-21 was significantly higher in plasma and in EBC of the NSCLC patients and miRNA-486 was significantly lower. This difference indicates a significantly improved diagnostic value, and suggests that these miRNAs could be clinically used as a first-line screening test in high-risk subjects.
Plasma and EBC microRNAs as early biomarkers of non-small-cell lung cancer / Mozzoni, Paola; Banda, Iris; Goldoni, Matteo; Corradi, Massimo; Tiseo, Marcello; Olga, Acampa; Balestra, Valeria; Ampollini, Luca; Angelo, Casalini; Carbognani, Paolo; Mutti, Antonio. - In: BIOMARKERS. - ISSN 1354-750X. - 18(2013), pp. 679-686. [10.3109/1354750X.2013.845610]
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