Pemphigus is a relatively rare autoimmune bullous disorder involving the skin and mucous epithelia. Clinically characterized by blisters and erosions, its histological hallmark is acantholysis induced by IgG antibodies (ab) against desmoglein 3 and/or desmoglein 1. The role of ab alone in inducing acantholysis is still a matter of debate as several mechanisms could be involved. Another intriguing area of research is the trigger factor inducing autoimmunity in pemphigus patients and the role of T and B cells in this process. This paper will review the data related to the mechanisms of acantholysis between keratinocytes and the role of T cell in this phenomenon.
Pemphigus: a complex T cell-dependent autoimmune disorder leading to acantholysis / C., Veldman; Feliciani, Claudio. - In: CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY. - ISSN 1080-0549. - 34:(2008), pp. 313-320. [10.1007/s12016-007-8045-y]
Pemphigus: a complex T cell-dependent autoimmune disorder leading to acantholysis.
FELICIANI, Claudio
2008-01-01
Abstract
Pemphigus is a relatively rare autoimmune bullous disorder involving the skin and mucous epithelia. Clinically characterized by blisters and erosions, its histological hallmark is acantholysis induced by IgG antibodies (ab) against desmoglein 3 and/or desmoglein 1. The role of ab alone in inducing acantholysis is still a matter of debate as several mechanisms could be involved. Another intriguing area of research is the trigger factor inducing autoimmunity in pemphigus patients and the role of T and B cells in this process. This paper will review the data related to the mechanisms of acantholysis between keratinocytes and the role of T cell in this phenomenon.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.