Using quasielastic neutron scattering, we investigated the diffusion of a model dmg (lidocaine, a molecule used in local anaesthetics and anti-arrhythmics) through a novel, water soluble, transdermal film (Patch-non-Patch (R)). The diffusivity of lidocaine is triggered by that of water. Up to hydration levels h = 15 (weight of water/total weight in %), water molecules are bound to the polymer matrix and no long range diffusion occurs. Lidocaine diffuses only when 'mobile' water is present (h > 0.15). The diffusivity of lidocaine is about three orders of magnitude lower than that of pure water, and it does not appreciably change up to h similar to 60.
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