Using quasielastic neutron scattering, we investigated the diffusion of a model dmg (lidocaine, a molecule used in local anaesthetics and anti-arrhythmics) through a novel, water soluble, transdermal film (Patch-non-Patch (R)). The diffusivity of lidocaine is triggered by that of water. Up to hydration levels h = 15 (weight of water/total weight in %), water molecules are bound to the polymer matrix and no long range diffusion occurs. Lidocaine diffuses only when 'mobile' water is present (h > 0.15). The diffusivity of lidocaine is about three orders of magnitude lower than that of pure water, and it does not appreciably change up to h similar to 60.
Dynamics of water and small molecules in bioadhesive polymer films / DI BARI, Maria; Padula, Cristina; Santi, Patrizia; Sonvico, Fabio; Barbieri, Stefano; C., Chiapponi; J., Ollivier; Deriu, Antonio. - In: JOURNAL OF THE PHYSICAL SOCIETY OF JAPAN. - ISSN 1347-4073. - 82:SA021(2013), pp. 1-8. [10.7566/JPSJS.82SA.SA021]
Dynamics of water and small molecules in bioadhesive polymer films
DI BARI, Maria;PADULA, Cristina;SANTI, Patrizia;SONVICO, Fabio;BARBIERI, Stefano;DERIU, Antonio
2013-01-01
Abstract
Using quasielastic neutron scattering, we investigated the diffusion of a model dmg (lidocaine, a molecule used in local anaesthetics and anti-arrhythmics) through a novel, water soluble, transdermal film (Patch-non-Patch (R)). The diffusivity of lidocaine is triggered by that of water. Up to hydration levels h = 15 (weight of water/total weight in %), water molecules are bound to the polymer matrix and no long range diffusion occurs. Lidocaine diffuses only when 'mobile' water is present (h > 0.15). The diffusivity of lidocaine is about three orders of magnitude lower than that of pure water, and it does not appreciably change up to h similar to 60.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
