Using quasielastic neutron scattering, we investigated the diffusion of a model dmg (lidocaine, a molecule used in local anaesthetics and anti-arrhythmics) through a novel, water soluble, transdermal film (Patch-non-Patch (R)). The diffusivity of lidocaine is triggered by that of water. Up to hydration levels h = 15 (weight of water/total weight in %), water molecules are bound to the polymer matrix and no long range diffusion occurs. Lidocaine diffuses only when 'mobile' water is present (h > 0.15). The diffusivity of lidocaine is about three orders of magnitude lower than that of pure water, and it does not appreciably change up to h similar to 60.

Dynamics of water and small molecules in bioadhesive polymer films / M. T. di Bari; C. Padula; P. Santi; F. Sonvico; S. Barbieri; C. Chiapponi; J. Ollivier; A. Deriu. - In: JOURNAL OF THE PHYSICAL SOCIETY OF JAPAN. - ISSN 1347-4073. - 82:SA021(2013), pp. 1-8. [10.7566/JPSJS.82SA.SA021]

Dynamics of water and small molecules in bioadhesive polymer films

DI BARI, Maria;PADULA, Cristina;SANTI, Patrizia;SONVICO, Fabio;BARBIERI, Stefano;DERIU, Antonio
2013

Abstract

Using quasielastic neutron scattering, we investigated the diffusion of a model dmg (lidocaine, a molecule used in local anaesthetics and anti-arrhythmics) through a novel, water soluble, transdermal film (Patch-non-Patch (R)). The diffusivity of lidocaine is triggered by that of water. Up to hydration levels h = 15 (weight of water/total weight in %), water molecules are bound to the polymer matrix and no long range diffusion occurs. Lidocaine diffuses only when 'mobile' water is present (h > 0.15). The diffusivity of lidocaine is about three orders of magnitude lower than that of pure water, and it does not appreciably change up to h similar to 60.
Dynamics of water and small molecules in bioadhesive polymer films / M. T. di Bari; C. Padula; P. Santi; F. Sonvico; S. Barbieri; C. Chiapponi; J. Ollivier; A. Deriu. - In: JOURNAL OF THE PHYSICAL SOCIETY OF JAPAN. - ISSN 1347-4073. - 82:SA021(2013), pp. 1-8. [10.7566/JPSJS.82SA.SA021]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11381/2661266
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