The present invention relates to calixarene derivatives functionalized at the upper and lower rim with arginine or guanidinylated amino acid units through proper variable spacers. The compounds of the invention interact with and non-covalently bind to nucleic acids, condense and transport them inside cells. These compounds can be used as non-viral vectors for cell transfection.
Functionalized calixarene derivatives for cell transfection / Ungaro, Rocco; Casnati, Alessandro; Donofrio, Gaetano; Sansone, Francesco; Bagnacani, Valentina. - (2013).
Functionalized calixarene derivatives for cell transfection
UNGARO, Rocco;CASNATI, Alessandro;DONOFRIO, Gaetano;SANSONE, Francesco;BAGNACANI, Valentina
2013-01-01
Abstract
The present invention relates to calixarene derivatives functionalized at the upper and lower rim with arginine or guanidinylated amino acid units through proper variable spacers. The compounds of the invention interact with and non-covalently bind to nucleic acids, condense and transport them inside cells. These compounds can be used as non-viral vectors for cell transfection.File in questo prodotto:
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