1. The protective activity of lansoprazole was evaluated on gastric mucosal lesions induced by intragastric 25% NaCl (1 ml/rat for 1 hr) and by indomethacin (20 mg/kg for 6 hr) in the rat and compared with that of omeprazole. 2. Lansoprazole (3, 10 and 30 mu mol/kg i.g.) dose-dependently prevented the formation of indomethacin-induced lesions, the inhibition being 99% at the highest dose. Omeprazole, 10 mu mol/kg i.g., enhanced the damage by indomethacin while higher doses caused a reduction, lesion index being reduced by 98% at 100 mu mol/kg. 3. Histologically in lansoprazole- as well as in omeprazole-pretreated rats, indomethacin-induced necrosis of the mucosa was absent, luminal epithelium being intact. 4. Lansoprazole (30, 100 and 300 mu mol/kg) and omeprazole (30, 100 and 300 mu mol/kg) dose dependently reduced the formation of lesions by hypertonic saline. 5. Present results indicate that lansoprazole and omeprazole protect the gastric mucosa in different experimental models of gastric ulceration.
Gastroprotective activity of the novel proton pump inhibitor lansoprazole in the rat / Morini, Giuseppina; Grandi, Daniela; Arcari, Maria Luisa; G., Bertaccini. - In: GENERAL PHARMACOLOGY. - ISSN 0306-3623. - 26:5(1995), pp. 1021-1025. [10.1016/0306-3623(94)00279-V]
Gastroprotective activity of the novel proton pump inhibitor lansoprazole in the rat
MORINI, Giuseppina;GRANDI, Daniela;ARCARI, Maria Luisa;
1995-01-01
Abstract
1. The protective activity of lansoprazole was evaluated on gastric mucosal lesions induced by intragastric 25% NaCl (1 ml/rat for 1 hr) and by indomethacin (20 mg/kg for 6 hr) in the rat and compared with that of omeprazole. 2. Lansoprazole (3, 10 and 30 mu mol/kg i.g.) dose-dependently prevented the formation of indomethacin-induced lesions, the inhibition being 99% at the highest dose. Omeprazole, 10 mu mol/kg i.g., enhanced the damage by indomethacin while higher doses caused a reduction, lesion index being reduced by 98% at 100 mu mol/kg. 3. Histologically in lansoprazole- as well as in omeprazole-pretreated rats, indomethacin-induced necrosis of the mucosa was absent, luminal epithelium being intact. 4. Lansoprazole (30, 100 and 300 mu mol/kg) and omeprazole (30, 100 and 300 mu mol/kg) dose dependently reduced the formation of lesions by hypertonic saline. 5. Present results indicate that lansoprazole and omeprazole protect the gastric mucosa in different experimental models of gastric ulceration.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.