The incomplete tachyphylaxis of the contractile response to the H-1-stimulants observed on guinea-pig oesophageal muscularis mucosae seems to be H-2- and H-3-antagonist as well as atropine- and tetrodotoxin-resistant. Lidocaine and eserine partially prevented this process probably by a mechanism independent of their main activity. The dualistic antagonism exerted by mepyramine and methysergide on reproducible histamine responses could be explained by a kinetic condition of "hemi-equilibrium state" together with changes of drug-receptor interaction and by non-specific properties of methysergide. On the whole, the present data indicate that the role of histamine in this tissue has still to be defined.
Anomalous responses to histamine stimulation of guinea-pig oesophageal muscularis mucosae / Barocelli, Elisabetta; M., Chiavarini; Morini, Giuseppina; Ballabeni, Vigilio; T., Vitali; Silva, Claudia; M., Impicciatore. - In: AGENTS AND ACTIONS. - ISSN 0065-4299. - 33:1-2(1991), pp. 173-176. [10.1007/BF01993159]
Anomalous responses to histamine stimulation of guinea-pig oesophageal muscularis mucosae
BAROCELLI, Elisabetta;MORINI, Giuseppina;BALLABENI, Vigilio;SILVA, Claudia;
1991-01-01
Abstract
The incomplete tachyphylaxis of the contractile response to the H-1-stimulants observed on guinea-pig oesophageal muscularis mucosae seems to be H-2- and H-3-antagonist as well as atropine- and tetrodotoxin-resistant. Lidocaine and eserine partially prevented this process probably by a mechanism independent of their main activity. The dualistic antagonism exerted by mepyramine and methysergide on reproducible histamine responses could be explained by a kinetic condition of "hemi-equilibrium state" together with changes of drug-receptor interaction and by non-specific properties of methysergide. On the whole, the present data indicate that the role of histamine in this tissue has still to be defined.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
