The H2-antagonist activity of thiazole derivatives, substituted on position 5 with urea-equivalent groups, has been tested on guinea-pig isolated atria stimulated by dimaprit. By comparing the activities of the 2,5-disubstituted thiazole derivatives with those of the corresponding 2,4-disubstituted derivatives it can be seen that the side-chain position is critical to activity and differently influences activity in the various series. The heteroaromatic ring atom sequence N-C-S-C-side chain is always associated with a low antagonist activity.

H2-receptor antagonist activity of N-methylthiourea, N-cyano-N'-methylguanidine, N-cyanoamidine, N-carbamoylamidine and N-sulfamoylamidine 5-substituted thiazole derivatives on guinea-pig atria / E. Barocelli; M. Chiavarini; G. Morini; P.V. Plazzi; T. Vitali; M. Impicciatore. - In: AGENTS AND ACTIONS. - ISSN 0065-4299. - 27:1-2(1989), pp. 195-197. [10.1007/BF02222237]

H2-receptor antagonist activity of N-methylthiourea, N-cyano-N'-methylguanidine, N-cyanoamidine, N-carbamoylamidine and N-sulfamoylamidine 5-substituted thiazole derivatives on guinea-pig atria

BAROCELLI, Elisabetta;MORINI, Giuseppina;
1989

Abstract

The H2-antagonist activity of thiazole derivatives, substituted on position 5 with urea-equivalent groups, has been tested on guinea-pig isolated atria stimulated by dimaprit. By comparing the activities of the 2,5-disubstituted thiazole derivatives with those of the corresponding 2,4-disubstituted derivatives it can be seen that the side-chain position is critical to activity and differently influences activity in the various series. The heteroaromatic ring atom sequence N-C-S-C-side chain is always associated with a low antagonist activity.
H2-receptor antagonist activity of N-methylthiourea, N-cyano-N'-methylguanidine, N-cyanoamidine, N-carbamoylamidine and N-sulfamoylamidine 5-substituted thiazole derivatives on guinea-pig atria / E. Barocelli; M. Chiavarini; G. Morini; P.V. Plazzi; T. Vitali; M. Impicciatore. - In: AGENTS AND ACTIONS. - ISSN 0065-4299. - 27:1-2(1989), pp. 195-197. [10.1007/BF02222237]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11381/2633668
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