A small library of 8-substituted 9-deazaxanthines has been prepared by late-stage diversification of an 8-bromo-9-deazaxanthine. By utilizing palladium-catalyzed cross-coupling reactions a single key precursor can be transformed into a variety of 8-substituted-9-deazaxanthine compounds. Three key 8-bromo-9-deazaxanthine intermediates were efficiently prepared from commercially available 6-chlorouracil in six steps.
Divergent synthesis of novel 9-deazaxanthine derivatives via late-stage cross-coupling reactions / Bartoccini, F; Piersanti, G; Mor, Marco; Tarzia, G; Minetti, P; Cabri, W.. - In: ORGANIC & BIOMOLECULAR CHEMISTRY. - ISSN 1477-0520. - STAMPA. - 10:44(2012), pp. 8860-8867. [10.1039/c2ob26516h]
Divergent synthesis of novel 9-deazaxanthine derivatives via late-stage cross-coupling reactions.
MOR, Marco;
2012-01-01
Abstract
A small library of 8-substituted 9-deazaxanthines has been prepared by late-stage diversification of an 8-bromo-9-deazaxanthine. By utilizing palladium-catalyzed cross-coupling reactions a single key precursor can be transformed into a variety of 8-substituted-9-deazaxanthine compounds. Three key 8-bromo-9-deazaxanthine intermediates were efficiently prepared from commercially available 6-chlorouracil in six steps.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
