The purpose of the present work was to study the in vitro distribution of acyclovir in human skin layers after iontophoresis, applied in order to increase the amount of drug in the basal epidermis, site of Herpes simplex infections. Experiments were done with Franz diffusion cells applying, as donor, acyclovir solutions (pH values: 3.0 and 7.4) or a commercial cream. Quantification of drug at different skin depths was performed by horizontal slicing of frozen skin, and drug extraction and analysis by high-performance liquid chromatography. Seven ...

In vitro acyclovir distribution in human skin layers after transdermal iontophoresis / N. M., Volpato; Nicoli, Sara; C., Laureri; Colombo, Paolo; Santi, Patrizia. - In: JOURNAL OF CONTROLLED RELEASE. - ISSN 0168-3659. - 50:1(1998), pp. 291-296.

In vitro acyclovir distribution in human skin layers after transdermal iontophoresis

NICOLI, Sara;COLOMBO, Paolo;SANTI, Patrizia
1998-01-01

Abstract

The purpose of the present work was to study the in vitro distribution of acyclovir in human skin layers after iontophoresis, applied in order to increase the amount of drug in the basal epidermis, site of Herpes simplex infections. Experiments were done with Franz diffusion cells applying, as donor, acyclovir solutions (pH values: 3.0 and 7.4) or a commercial cream. Quantification of drug at different skin depths was performed by horizontal slicing of frozen skin, and drug extraction and analysis by high-performance liquid chromatography. Seven ...
1998
In vitro acyclovir distribution in human skin layers after transdermal iontophoresis / N. M., Volpato; Nicoli, Sara; C., Laureri; Colombo, Paolo; Santi, Patrizia. - In: JOURNAL OF CONTROLLED RELEASE. - ISSN 0168-3659. - 50:1(1998), pp. 291-296.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2586848
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