Thiocolchicoside, a muscle-relaxant agent, is administered by the oral, intra-muscular and topical route. After oral administration the extent of bioavailability compared with intra- muscular administration is low, due to a first pass effect. In this paper, the delivery of thiocolchicoside through oral mucosa is studied to improve the bioavailability. Thiocolchicoside in vitro permeation through porcine oral mucosa and in vivo buccal transport in humans were investigated. Two dosage forms, a bioadhesive disc and a fast ...

Buccal delivery of thiocolchicoside: in vitro and in vivo permeation studies / M., Artusi; Santi, Patrizia; Colombo, Paolo; He, Junginger. - In: INTERNATIONAL JOURNAL OF PHARMACEUTICS. - ISSN 0378-5173. - 250:1(2003), pp. 203-213.

Buccal delivery of thiocolchicoside: in vitro and in vivo permeation studies

SANTI, Patrizia;COLOMBO, Paolo;
2003-01-01

Abstract

Thiocolchicoside, a muscle-relaxant agent, is administered by the oral, intra-muscular and topical route. After oral administration the extent of bioavailability compared with intra- muscular administration is low, due to a first pass effect. In this paper, the delivery of thiocolchicoside through oral mucosa is studied to improve the bioavailability. Thiocolchicoside in vitro permeation through porcine oral mucosa and in vivo buccal transport in humans were investigated. Two dosage forms, a bioadhesive disc and a fast ...
2003
Buccal delivery of thiocolchicoside: in vitro and in vivo permeation studies / M., Artusi; Santi, Patrizia; Colombo, Paolo; He, Junginger. - In: INTERNATIONAL JOURNAL OF PHARMACEUTICS. - ISSN 0378-5173. - 250:1(2003), pp. 203-213.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2575245
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