Drug constant release is not always the desired solution for controlled drug administration; some therapeutic situations require consecutive pulses of active principle A biphasic oral delivery system able to release an immediate dose of therapeutic agent as well as a further pulse of drug after some hours could be interesting In order to obtain such desired releasing performances, a new system (three layer tablet) has been designed with the following characteristics-an energy source, able to deliver the two divided doses of ...
A new ibuprofen pulsed release oral dosage form / U Conte; P Colombo; A La Manna; A Gazzaniga; ME Sangalli; P Giunchedi. - In: DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY. - ISSN 0363-9045. - 15:14-16(1989), pp. 2583-2596.
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