The preparation and characterization of microparticles produced from a new class of functionalized, biodegradable, comblike graft copolymers is presented. The copolymers are polyester–polyamino acid hybrids, composed of a poly (L-lactic acid–co-L-lysine)(PLAL) backbone, and poly (L-lysine), poly (D, L-alanine) or poly (L-aspartic acid) side chains extending from the lysine residues of PLAL. The microparticles have been characterized with regard to their surface properties, morphology, and size. Thus, electron spectroscopy ...
Microparticles of novel branched copolymers of lactic acid and amino acids: preparation and characterization / Giovanni, Caponetti; Jeffrey S., Hrkach; Burkhard, Kriwet; Melissa, Poh; Noah, Lotan; Colombo, Paolo; Robert, Langer. - In: JOURNAL OF PHARMACEUTICAL SCIENCES. - ISSN 0022-3549. - 88:1(1999), pp. 136-141.
Microparticles of novel branched copolymers of lactic acid and amino acids: preparation and characterization
COLOMBO, Paolo;
1999-01-01
Abstract
The preparation and characterization of microparticles produced from a new class of functionalized, biodegradable, comblike graft copolymers is presented. The copolymers are polyester–polyamino acid hybrids, composed of a poly (L-lactic acid–co-L-lysine)(PLAL) backbone, and poly (L-lysine), poly (D, L-alanine) or poly (L-aspartic acid) side chains extending from the lysine residues of PLAL. The microparticles have been characterized with regard to their surface properties, morphology, and size. Thus, electron spectroscopy ...| File | Dimensione | Formato | |
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