Matrices of reduced dimensions of either inert or swellable polymers for multiple-unit administration, containing diprophylline as the model drug, were made by compression. Some swellable mini-matrices prepared from poly (vinyl alcohol) were externally crosslinked by soaking in an acidic formalin solution, and subsequent drying and exposure to UV or thermal energy sources. The release kinetics of the model drug from the mini-matrices was investigated by analyzing the early time portion of the release curves according to a ...
Compressed polymeric mini-matrices for drug release control / Colombo, Paolo; U., Conte; C., Caramella; A., Gazzaniga; A., La Manna. - In: JOURNAL OF CONTROLLED RELEASE. - ISSN 0168-3659. - 1:4(1985), pp. 283-289.
Compressed polymeric mini-matrices for drug release control
COLOMBO, Paolo;
1985-01-01
Abstract
Matrices of reduced dimensions of either inert or swellable polymers for multiple-unit administration, containing diprophylline as the model drug, were made by compression. Some swellable mini-matrices prepared from poly (vinyl alcohol) were externally crosslinked by soaking in an acidic formalin solution, and subsequent drying and exposure to UV or thermal energy sources. The release kinetics of the model drug from the mini-matrices was investigated by analyzing the early time portion of the release curves according to a ...I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
