The mucoadhesive capacity of poly (2-hydroxyethyl methacrylate)(PHEMA) microspheres was studied in contact with Sprague-Dawley rat jejunum at pH= 6 and at 22° C. Dry PHEMA microparticles exhibited adequate mucoadhesive capacity, which was independent of nominal crosslinking ratio. When PHEMA microparticles were loaded with linear PEO chains of molecular weight 1000, the mucoadhesive capacity increased significantly, almost doubling. This behavior was attributed to a significant increase of the PEO chains ...
Mucoadhesion of poly (2-hydroxyethyl methacrylate) is improved when linear poly (ethylene oxide) chains are added to the polymer network / Alessia De, Ascentiis; Janet L., Degrazia; Christopher N., Bowman; Colombo, Paolo; Nikolaos A., Peppas. - In: JOURNAL OF CONTROLLED RELEASE. - ISSN 0168-3659. - 33:1(1995), pp. 197-201.
Mucoadhesion of poly (2-hydroxyethyl methacrylate) is improved when linear poly (ethylene oxide) chains are added to the polymer network
COLOMBO, Paolo;
1995-01-01
Abstract
The mucoadhesive capacity of poly (2-hydroxyethyl methacrylate)(PHEMA) microspheres was studied in contact with Sprague-Dawley rat jejunum at pH= 6 and at 22° C. Dry PHEMA microparticles exhibited adequate mucoadhesive capacity, which was independent of nominal crosslinking ratio. When PHEMA microparticles were loaded with linear PEO chains of molecular weight 1000, the mucoadhesive capacity increased significantly, almost doubling. This behavior was attributed to a significant increase of the PEO chains ...| File | Dimensione | Formato | |
|---|---|---|---|
|
Mucoadhesion of poly(2-hydroxyethyl methacrylate).pdf
non disponibili
Tipologia:
Documento in Post-print
Licenza:
NON PUBBLICO - Accesso privato/ristretto
Dimensione
347 kB
Formato
Adobe PDF
|
347 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
|
1-s2.0-016836599400087B-main.pdf
non disponibili
Tipologia:
Documento in Post-print
Licenza:
NON PUBBLICO - Accesso privato/ristretto
Dimensione
347 kB
Formato
Adobe PDF
|
347 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
