Novel semicrystalline, poly (vinyl alcohol)(PVA)-based phase erosion systems were developed. The rate of drug release from these systems is controlled by the rate of crystal dissolution. PVA devices loaded with metronidazole were exposed to temperatures ranging from 90 to 120 C for times of 10–90 min to obtain samples with different degrees of crystallinity. Degrees of crystallinity were measured by differential scanning calorimetry and attenuated total reflectance Fourier transform infrared spectroscopy. In vitro release of ...
Crystal dissolution‐controlled release systems. II. Metronidazole release from semicrystalline poly (vinyl alcohol) systems / Surya K., Mallapragada; Nikolaos A., Peppas; Colombo, Paolo. - In: JOURNAL OF BIOMEDICAL MATERIALS RESEARCH. - ISSN 0021-9304. - 36:1(1998), pp. 125-130.
Crystal dissolution‐controlled release systems. II. Metronidazole release from semicrystalline poly (vinyl alcohol) systems
COLOMBO, Paolo
1998-01-01
Abstract
Novel semicrystalline, poly (vinyl alcohol)(PVA)-based phase erosion systems were developed. The rate of drug release from these systems is controlled by the rate of crystal dissolution. PVA devices loaded with metronidazole were exposed to temperatures ranging from 90 to 120 C for times of 10–90 min to obtain samples with different degrees of crystallinity. Degrees of crystallinity were measured by differential scanning calorimetry and attenuated total reflectance Fourier transform infrared spectroscopy. In vitro release of ...I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
