In this work the production of auto-assembled nanoparticles obtained by the mixing of chitosan and lecithin is presented. The size and surface charge of the nanoparticles were studied as function of the weight ratio between components, the viscosity of the polysaccharide and the pH of the colloidal suspension. In order to elucidate the structure of nanoparticles, micro-FT-IR and elastic neutron scattering experiments have been performed. Results evidenced a strong electrostatic interaction between components and a structure ...
Formation of self-organized nanoparticles by lecithin/chitosan ionic interaction / Sonvico, Fabio; A., Cagnani; Rossi, Alessandra; S., Motta; DI BARI, Maria; Cavatorta, Fabrizio; Mj, Alonso; Deriu, Antonio; Colombo, Paolo. - In: INTERNATIONAL JOURNAL OF PHARMACEUTICS. - ISSN 0378-5173. - 324:1(2006), pp. 67-73. [10.1016/j.ijpharm.2006.06.036]
Formation of self-organized nanoparticles by lecithin/chitosan ionic interaction
SONVICO, Fabio;ROSSI, Alessandra;DI BARI, Maria;CAVATORTA, Fabrizio;DERIU, Antonio;COLOMBO, Paolo
2006-01-01
Abstract
In this work the production of auto-assembled nanoparticles obtained by the mixing of chitosan and lecithin is presented. The size and surface charge of the nanoparticles were studied as function of the weight ratio between components, the viscosity of the polysaccharide and the pH of the colloidal suspension. In order to elucidate the structure of nanoparticles, micro-FT-IR and elastic neutron scattering experiments have been performed. Results evidenced a strong electrostatic interaction between components and a structure ...| File | Dimensione | Formato | |
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