The swelling behavior of and solute transport in swellable, ionic copolymers of 2- hydroxyethyl methacrylate and methacrylic acid was studied for a wide range of copolymer compositions. The swelling behavior was determined by investigating the time-dependent change of the swelling and erosion front positions and the associated gel layer as a function of the percentage of the ionic component (MAA). Release of theophylline and metoclopramide-HCl were studied as a function of time. The swelling and release ...
Solubility effects on drug transport through pH-sensitive, swelling-controlled release systems: Transport of theophylline and metoclopramide monohydrochloride / Bettini, Ruggero; Colombo, Paolo; Nikolaos A., Peppas. - In: JOURNAL OF CONTROLLED RELEASE. - ISSN 0168-3659. - 37:1(1995), pp. 105-111.
Solubility effects on drug transport through pH-sensitive, swelling-controlled release systems: Transport of theophylline and metoclopramide monohydrochloride
BETTINI, Ruggero;COLOMBO, Paolo;
1995-01-01
Abstract
The swelling behavior of and solute transport in swellable, ionic copolymers of 2- hydroxyethyl methacrylate and methacrylic acid was studied for a wide range of copolymer compositions. The swelling behavior was determined by investigating the time-dependent change of the swelling and erosion front positions and the associated gel layer as a function of the percentage of the ionic component (MAA). Release of theophylline and metoclopramide-HCl were studied as a function of time. The swelling and release ...I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
