Atomic force microscopy (AFM) was used to investigate drug-carrier interactions between beclometasone dipropionate (BDP) and a series of untreated and modified lactose surfaces. This quantitative information was correlated with bulk characterization methods and an in-vitro study. Modified lactose surfaces were prepared using a proprietary process referred to as “particle smoothing” to obtain smooth carrier surfaces with or without the presence of magnesium stearate. The engineering of lactose carrier surfaces using the ...
Characterization of a surface modified dry powder inhalation carrier prepared by “particle smoothing” / Paul, Young; Daniela, Cocconi; Colombo, Paolo; Bettini, Ruggero; Robert, Price; Dan, Steele; Michael, Tobyn. - In: JOURNAL OF PHARMACY AND PHARMACOLOGY. - ISSN 0022-3573. - 54:10(2002), pp. 1339-1344.
Characterization of a surface modified dry powder inhalation carrier prepared by “particle smoothing”
COLOMBO, Paolo;BETTINI, Ruggero;
2002-01-01
Abstract
Atomic force microscopy (AFM) was used to investigate drug-carrier interactions between beclometasone dipropionate (BDP) and a series of untreated and modified lactose surfaces. This quantitative information was correlated with bulk characterization methods and an in-vitro study. Modified lactose surfaces were prepared using a proprietary process referred to as “particle smoothing” to obtain smooth carrier surfaces with or without the presence of magnesium stearate. The engineering of lactose carrier surfaces using the ...I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
