The majority of oral drug delivery systems (DDS) are matrix-based. Swellable matrices are monolithic systems prepared by compression of a powdered mixture of a hydrophilic polymer and a drug. Their success is linked to the established tabletting technology of manufacturing. Swellable matrix DDS must be differentiated from true swelling-controlled delivery systems. This review focuses on hydrophilic swellable matrix tablets as controlled DDS. Gel-layer behaviour, front movement and release are described to show the ...
Swellable matrices for controlled drug delivery: gel-layer behaviour, mechanisms and optimal performance / Colombo, Paolo; Bettini, Ruggero; Santi, Patrizia; Nicholas, Peppas. - In: PHARMACEUTICAL SCIENCE & TECHNOLOGY TODAY. - ISSN 1461-5347. - 3:6(2000), pp. 198-204.
Swellable matrices for controlled drug delivery: gel-layer behaviour, mechanisms and optimal performance
COLOMBO, Paolo;BETTINI, Ruggero;SANTI, Patrizia;
2000-01-01
Abstract
The majority of oral drug delivery systems (DDS) are matrix-based. Swellable matrices are monolithic systems prepared by compression of a powdered mixture of a hydrophilic polymer and a drug. Their success is linked to the established tabletting technology of manufacturing. Swellable matrix DDS must be differentiated from true swelling-controlled delivery systems. This review focuses on hydrophilic swellable matrix tablets as controlled DDS. Gel-layer behaviour, front movement and release are described to show the ...I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
