The synthesis and resolution of 1-(2-methoxy-l-naphthyl)isoquinoline and 1-(2-methylthio-1- naphthyl)isoquinoline is reported. These ligands were assessed in the enantioselective palladium catalyzed allylic substitution of 1,3-diphenylprop-2-enyl acetate with dimethylmalonate. Enantioselectivity up to 68 % was obtained.

Enantiomerically pure 1-(2-methoxy-l-naphthyl) and 1-(2- methylthio-l-naphthyl)isoquinoline: two new axially chiral N-O and N-S ligands for asymmetric catalysis / Giorgio, Chelucci; Bacchi, Alessia; Davide, Fabbri; Antonio, Saba; Fausta, Ulgheri. - In: TETRAHEDRON LETTERS. - ISSN 0040-4039. - 40:(1999), pp. 553-556.

Enantiomerically pure 1-(2-methoxy-l-naphthyl) and 1-(2- methylthio-l-naphthyl)isoquinoline: two new axially chiral N-O and N-S ligands for asymmetric catalysis

BACCHI, Alessia;
1999-01-01

Abstract

The synthesis and resolution of 1-(2-methoxy-l-naphthyl)isoquinoline and 1-(2-methylthio-1- naphthyl)isoquinoline is reported. These ligands were assessed in the enantioselective palladium catalyzed allylic substitution of 1,3-diphenylprop-2-enyl acetate with dimethylmalonate. Enantioselectivity up to 68 % was obtained.
1999
Enantiomerically pure 1-(2-methoxy-l-naphthyl) and 1-(2- methylthio-l-naphthyl)isoquinoline: two new axially chiral N-O and N-S ligands for asymmetric catalysis / Giorgio, Chelucci; Bacchi, Alessia; Davide, Fabbri; Antonio, Saba; Fausta, Ulgheri. - In: TETRAHEDRON LETTERS. - ISSN 0040-4039. - 40:(1999), pp. 553-556.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2536920
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