The synthesis and resolution of 1-(2-methoxy-l-naphthyl)isoquinoline and 1-(2-methylthio-1- naphthyl)isoquinoline is reported. These ligands were assessed in the enantioselective palladium catalyzed allylic substitution of 1,3-diphenylprop-2-enyl acetate with dimethylmalonate. Enantioselectivity up to 68 % was obtained.
Enantiomerically pure 1-(2-methoxy-l-naphthyl) and 1-(2- methylthio-l-naphthyl)isoquinoline: two new axially chiral N-O and N-S ligands for asymmetric catalysis / Giorgio, Chelucci; Bacchi, Alessia; Davide, Fabbri; Antonio, Saba; Fausta, Ulgheri. - In: TETRAHEDRON LETTERS. - ISSN 0040-4039. - 40:(1999), pp. 553-556.
Enantiomerically pure 1-(2-methoxy-l-naphthyl) and 1-(2- methylthio-l-naphthyl)isoquinoline: two new axially chiral N-O and N-S ligands for asymmetric catalysis
BACCHI, Alessia;
1999-01-01
Abstract
The synthesis and resolution of 1-(2-methoxy-l-naphthyl)isoquinoline and 1-(2-methylthio-1- naphthyl)isoquinoline is reported. These ligands were assessed in the enantioselective palladium catalyzed allylic substitution of 1,3-diphenylprop-2-enyl acetate with dimethylmalonate. Enantioselectivity up to 68 % was obtained.| File | Dimensione | Formato | |
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